VILON
What Is VILON?
Vilon is a synthetic dipeptide bioregulator consisting of lysine and glutamic acid (Lys-Glu) that acts as an immunomodulator and geroprotective agent. It primarily functions by activating gene expression through chromatin deheterochromatinization, enhancing T-cell differentiation, and stimulating digestive enzyme activity. Vilon has been studied for applications in cancer therapy, immune system support, anti-aging interventions, and improving intestinal function in elderly populations.
VILON Research & Studies
01 Bioregulator Vilon-induced reactivation of chromatin in cultured lymphocytes from old people ▸
Vilon induced chromatin deheterochromatinization in lymphocytes from elderly individuals, reactivating ribosomal genes and releasing repressed genes while preserving structural heterochromatin integrity.
View Study (PubMed)02 Effect of vilon on biological age and lifespan in mice ▸
Subcutaneous Vilon administration increased physical activity and endurance, prolonged lifespan, and prevented spontaneous neoplasm development in female CBA mice without adverse effects.
View Study (PubMed)03 Application of peptide bioregulator in complex treatment of elderly cancer patients ▸
Vilon inclusion in cancer treatment schemes increased 2-year survival rates, prevented post-operative complications, and improved quality of life in elderly patients with stage III rectal and colon cancer.
View Study (PubMed)04 Immunomodulating effects of Vilon and its analogue in the culture of human and animal thymus cells ▸
Vilon increased CD5 lymphocyte differentiation marker expression in thymic cells and induced T-cell precursor differentiation towards CD4+ T-helpers, demonstrating immunomodulatory and antiallergic activity.
View Study (PubMed)05 Effects of short peptides on lymphocyte chromatin in senile subjects ▸
Vilon activated ribosome genes, induced chromatin decondensation, and released genes repressed by age-specific heterochromatinization in leukocytes of individuals aged 75-88 years.
View Study (PubMed)06 Effect of the dipeptide vilon on activity of digestive enzyme in rats of various ages ▸
Oral Vilon administration increased digestive enzyme activity in the gastrointestinal tract, with most pronounced effects in 11-month-old rats, diminishing age-related differences in enzyme function.
View Study (PubMed)07 Effects of short peptides on thymocyte blast transformation and signal transduction along the sphingomyelin pathway ▸
Vilon produced the most potent comitogenic effect on thymocyte proliferation and significantly stimulated sphingomyelinase activity in mouse thymocyte membranes compared to other peptides tested.
View Study (PubMed)08 Immunohistochemical and morphometric analysis of effects of vilon and epithalon on functional morphology of radiosensitive organs ▸
Vilon stimulated thymocyte proliferative activity and enhanced stem cell proliferative potential in the intestine, promoting post-radiation recovery of critical organs in irradiated rats.
View Study (PubMed)VILON User Reviews & Experiences
*Based on large scale analysis of publicly available user experiences
Limited English-language Reddit discussions on Vilon. This Khavinson peptide is primarily used in Russia and Eastern European countries for immune system support.
VILON Benefits, Dosage & Side Effects
- Immune System Activation: Enhances T-cell differentiation and lymphocyte function through increased CD5 marker expression
- Chromatin Reactivation: Induces gene expression by deheterochromatinizing facultative heterochromatin in elderly individuals
- Digestive Enhancement: Improves activity of digestive enzymes (maltase, alkaline phosphatase, dipeptidases) particularly in aged subjects
- Longevity Support: Demonstrated increased lifespan and physical endurance in animal models with prevention of spontaneous tumor development
- Anti-Aging Applications: Effectively reverses age-related gene silencing and chromatin condensation in elderly subjects aged 75-88 years
- Cancer Therapy: Improved 2-year survival rates and quality of life when added to treatment regimens for elderly stage III colon/rectal cancer patients
- Radiation Protection: Stimulates post-radiation recovery of thymus and intestinal tissue in animal models exposed to 6 Gy gamma-irradiation
- Age-Related Improvement: Most pronounced benefits observed in older animals and humans, diminishing age-related functional differences
- Research Dosing: 1 mg/kg subcutaneous injection used in animal longevity studies with positive outcomes
- Cancer Treatment Protocol: Applied as immunomodulator addition to standard radio/chemotherapy regimens in clinical oncology settings
- Oral Administration: Given per os (orally) for 1 month in studies examining digestive enzyme enhancement
- Culture Concentrations: 5 ng/ml effective dose in tissue culture studies for stimulating apoptosis and cell proliferation
- Drug Interactions: Combined use with cyclophosphamide decreased survival in tumor-bearing mice; synchronous use with cytostatic drugs not recommended
- Minimal Adverse Effects: Long-term administration showed no unfavorable effects on animal development in chronic studies
- Tissue Specificity: Effects are tissue-specific; primarily stimulates thymic tissue rather than having systemic broad-spectrum activity
- Safety Profile: No significant side effects reported in elderly cancer patients or aged subjects in clinical trials
- Research Status: Primarily available as research peptide; studied extensively in Russian medical institutions since early 2000s
- Clinical Use: Applied in specialized oncology and gerontology settings in Russia as adjuvant therapy for elderly cancer patients
- Synthetic Production: Manufactured as synthetic dipeptide (Lys-Glu) for consistent pharmaceutical quality and research applications
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