TRANS-RESVERATROL
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What Is TRANS-RESVERATROL?
Trans-resveratrol is a polyphenolic compound found naturally in grapes, berries, and other plants that acts as a phytoestrogen and activates SIRT1 pathways. It has demonstrated antioxidant, anti-inflammatory, and potential anti-aging properties through multiple mechanisms including NAD+ metabolism support and mitochondrial function enhancement. Research suggests benefits for bone density, cardiovascular health, glucose metabolism, and longevity, though bioavailability is enhanced when consumed with dietary fats.
TRANS-RESVERATROL Research & Studies
01 Regular Supplementation With Resveratrol Improves Bone Mineral Density in Postmenopausal Women: A Randomized, Placebo-Controlled Trial ▸
A 24-month randomized controlled trial found that resveratrol supplementation significantly improved bone mineral density in postmenopausal women, supporting its bone-protective role similar to effects seen in animal models of osteoporosis.
View Study (PubMed)02 Role of resveratrol supplementation in regulation of glucose hemostasis, inflammation and oxidative stress in patients with diabetes mellitus type 2: A randomized, placebo-controlled trial ▸
200mg daily resveratrol supplementation for 24 weeks significantly improved glucose homeostasis, reduced inflammatory markers (TNF-α, IL-6, hs-CRP), and decreased oxidative stress in type 2 diabetic patients on oral hypoglycemic drugs.
View Study (PubMed)03 Gut microbiota-derived 4-hydroxyphenylacetic acid from resveratrol supplementation prevents obesity through SIRT1 signaling activation ▸
Resveratrol supplementation ameliorated high-fat-diet-induced obesity by enhancing beneficial gut bacteria (Akkermansia, Bacteroides, Blautia) and producing metabolites that activate SIRT1 signaling, as confirmed through antibiotic depletion and fecal microbiota transplantation studies.
View Study (PubMed)04 Trans-resveratrol supplement lowers lipid peroxidation responses of exercise in male Wistar rats ▸
Trans-resveratrol supplementation demonstrated antioxidant properties by reducing lipid peroxidation and protecting against exercise-induced oxidative damage in muscle fibers of male rats.
View Study (PubMed)05 Effects of Mediterranean Diet, Curcumin, and Resveratrol on Mild-to-Moderate Active Ulcerative Colitis: A Multicenter Randomized Clinical Trial ▸
An 8-week trial combining Mediterranean diet with resveratrol supplementation showed improvements in disease activity, inflammatory markers, and quality of life in patients with mild-to-moderate active ulcerative colitis.
View Study (PubMed)06 Efficacy and safety of dietary polyphenol supplementation in the treatment of non-alcoholic fatty liver disease: A systematic review and meta-analysis ▸
Systematic review and meta-analysis found that dietary polyphenol supplementation including resveratrol showed efficacy in treating non-alcoholic fatty liver disease with favorable safety profiles.
View Study (PubMed)07 Trans-Resveratrol Enhances the Anticoagulant Activity of Warfarin in a Mouse Model ▸
Trans-resveratrol at 0.5% dietary concentration enhanced warfarin's anticoagulant effects in mice and slightly increased CYP1A1 activity, suggesting potential drug interactions requiring monitoring in patients taking anticoagulants.
View Study (PubMed)08 Immunotoxicity studies of trans-resveratrol in male B(6)C(3)F(1)/N mice ▸
A 28-day study in mice found no treatment-related immunotoxic effects from trans-resveratrol at doses up to 2500 mg/kg/day, with no impacts on humoral, cell-mediated, or innate immune function despite previous findings of decreased thymus weight.
View Study (PubMed)TRANS-RESVERATROL User Reviews & Experiences
*Based on large scale analysis of publicly available user experiences
Users report mixed experiences with resveratrol, with many longevity-focused biohackers including it in their stacks alongside NMN for anti-aging benefits. However, concerns exist about bioavailability, optimal dosing, effectiveness compared to marketing claims, and some reports of side effects, with debates about whether benefits justify the cost.
TRANS-RESVERATROL Benefits, Dosage & Side Effects
- Energy Enhancement: Users report sustained energy levels throughout the day, particularly when combined with NMN, with some experiencing 'insane amounts of energy' even with poor sleep
- Anti-Inflammatory Benefits: Multiple users incorporate resveratrol for general inflammation reduction, joint health, and recovery support, often stacking with curcumin and quercetin
- Longevity Support: Primary use case focuses on anti-aging and epigenetic age reversal, with users following protocols inspired by longevity research (David Sinclair approach)
- Metabolic Effects: Reports of improved glucose control and metabolic function, particularly when used as part of comprehensive health protocols including diet modification
- Bioavailability Concerns: Users emphasize that resveratrol must be dissolved in fat (olive oil, coconut oil) for optimal absorption, with claims of 10-100x increased bioavailability when taken with dietary fats
- Synergistic Effects: Most effective when stacked with other compounds like NMN, TMG, quercetin, and curcumin rather than as standalone supplement
- Dose-Response Variation: Effectiveness appears highly individual, with some users noticing benefits at 500mg while others follow David Sinclair's 1g daily protocol
- Mixed Evidence: Skepticism exists about whether resveratrol optimizes flawed testing methods or provides genuine benefits, with some studies published after initial hype suggesting potential DNA replicative stress
- Standard Range: Most common dosing is 500mg-1000mg daily of trans-resveratrol, typically taken in morning with fat source
- David Sinclair Protocol: 1 gram daily is frequently referenced as the high-end dose used by longevity researchers, though this exceeds typical supplement bottle recommendations
- Cost Considerations: Users often reduce from 1g to 500mg doses to balance effectiveness with expense, reporting 80% of benefits at half the dose
- Timing and Form: Taken with morning meals containing fat, with some users preferring liposomal forms for enhanced absorption despite higher cost
- Kidney Concerns: Some users report warnings about long-term kidney damage with extended resveratrol use, leading to discontinuation
- Exercise Blunting: Reports that resveratrol may blunt the beneficial effects of exercise, similar to metformin, causing concern for fitness-focused users
- Warfarin Interaction: Research confirms resveratrol enhances anticoagulant effects of blood thinners, requiring medical monitoring for users on such medications
- Individual Reactions: Varied reports of side effects at higher doses (600-1200mg) that were 'not worth whatever benefit,' though specifics often undetailed
- Quality Concerns: Significant concerns about resveratrol supplement scams and purity, with users emphasizing need for verified trans-resveratrol rather than low-purity products containing ineffective cis-resveratrol
- Brand Recommendations: Toniiq and quality brands frequently mentioned for quality and third-party testing, though quality brands criticized for high prices; users recommend verifying 99% trans-resveratrol purity
- Cost Factor: Described as 'not cheap' with monthly costs varying significantly by brand and dosage, leading many users to seek bulk sources or lower doses to manage expenses
Related Compounds
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