SPERMIDINE
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What Is SPERMIDINE?
Spermidine is a naturally occurring polyamine compound found in various foods and produced by the body that acts as a potent autophagy inducer. It works by stimulating cellular cleanup processes, protecting against age-related decline, and supporting cardiovascular, cognitive, and metabolic health. Research suggests it may extend lifespan and reduce mortality risk through its effects on cellular maintenance and anti-inflammatory mechanisms.
SPERMIDINE Research & Studies
01 Spermidine in health and disease ▸
Comprehensive review identifying spermidine as a caloric restriction mimetic that delays aging and protects from age-associated diseases by inducing autophagy and cellular renewal processes.
View Study (PubMed)02 Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline: A Randomized Clinical Trial ▸
Clinical trial in older adults showing spermidine supplementation improved cognitive performance and various biomarkers in participants with subjective cognitive decline.
View Study (PubMed)03 Dietary spermidine improves cognitive function ▸
Study demonstrating that dietary spermidine supplementation enhances cognitive function through mechanisms involving autophagy and neuroprotection in animal models and human observations.
View Study (PubMed)04 Spermidine delays aging in humans ▸
Epidemiological evidence showing higher dietary spermidine intake correlates with reduced mortality risk equivalent to being 5.7 years younger in biological age.
View Study (PubMed)05 Spermidine is essential for fasting-mediated autophagy and longevity ▸
Research demonstrating spermidine's critical role in mediating the autophagy-inducing and lifespan-extending effects of fasting and caloric restriction.
View Study (PubMed)06 Spermidine reduces neuroinflammation and soluble amyloid beta in an Alzheimer's disease mouse model ▸
Animal study showing spermidine reduced neuroinflammation and amyloid-beta accumulation, suggesting potential protective effects against Alzheimer's disease pathology.
View Study (PubMed)07 Safety and tolerability of spermidine supplementation in mice and older adults with subjective cognitive decline ▸
Safety study confirming spermidine supplementation is well-tolerated in older adults with minimal adverse effects, supporting its viability for long-term use.
View Study (PubMed)08 Protective Role of Spermidine in Colitis and Colon Carcinogenesis ▸
Research demonstrating spermidine's protective effects against inflammatory bowel disease and colon cancer development through anti-inflammatory mechanisms.
View Study (PubMed)SPERMIDINE User Reviews & Experiences
*Based on large scale analysis of publicly available user experiences
Users generally report positive experiences with spermidine supplementation, particularly for longevity and cognitive benefits, though effects are subtle and take time. Most users take it as part of a comprehensive longevity stack rather than for immediate noticeable effects.
SPERMIDINE Benefits, Dosage & Side Effects
- Autophagy Induction: Users report increased cellular cleanup and detoxification processes, though effects are not immediately noticeable
- Cognitive Support: Some users experience improved mental clarity and memory, particularly in combination with other supplements
- Body Heat Response: Multiple users report experiencing increased body heat after taking spermidine, suggesting metabolic activation
- Subtle Long-term Benefits: Most effects are gradual and related to healthy aging rather than immediate performance enhancement
- Longevity Marker: Studies show strongest correlation with reduced mortality among 146 nutrients tested, with effects comparable to being 5.7 years younger
- Dietary vs Supplemental: Research emphasizes dietary sources (mushrooms, beans, wheat germ) may be more effective than high-dose supplementation
- Gradual Impact: Users typically don't notice dramatic short-term effects, with benefits appearing over weeks to months of consistent use
- Synergistic Effects: Often combined with other longevity supplements (NMN, resveratrol) as part of comprehensive anti-aging protocols
- Typical Supplemental Dose: 1-10mg daily from supplements, with most commercial products containing 1-10mg per serving
- David Sinclair Protocol: Referenced taking 1g daily, though this appears to be a misstatement as studies use 1-2mg ranges
- Dietary Sources: 2 tablespoons wheat germ provides approximately 6-12mg, making food sources highly cost-effective
- Clinical Study Doses: Human trials typically use 1.2mg daily with positive results on cognition and biomarkers
- Increased Body Heat: Common reported side effect requiring some users to microdose to avoid intense warming sensation
- Exercise Odor: Some users report unusual body odor during intense exercise on days they take spermidine
- Sleep Disturbance: Higher doses may cause sleep issues in sensitive individuals, leading users to take lower amounts
- Minimal Serious Effects: Generally well-tolerated with safety studies confirming low risk profile in long-term use
- Multiple Brands: Available from DoNotAge (8-16mg), Primeadine (lower dose with wheat germ), DoubleWood (10mg), and other supplement companies
- Cost Considerations: Relatively expensive compared to obtaining spermidine from dietary sources like wheat germ, mushrooms, or beans
- Food Sources Preferred: Many users and researchers recommend getting spermidine from whole food sources rather than isolated supplements for better efficacy
Related Compounds
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