SODIUM BUTYRATE
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What Is SODIUM BUTYRATE?
Sodium butyrate is the salt form of butyric acid, a short-chain fatty acid (SCFA) produced by the gut microbiota that acts as a potent histone deacetylase (HDAC) inhibitor. It modulates gene expression to improve mitochondrial function, regulate energy metabolism, and support intestinal barrier integrity.
SODIUM BUTYRATE Research & Studies
01 Sodium butyrate epigenetically modulates high-fat diet-induced skeletal muscle mitochondrial adaptation, obesity and insulin resistance through nucleosome positioning ▸
This study demonstrates that sodium butyrate can prevent high-fat diet-induced obesity and insulin resistance by improving mitochondrial function and oxidative metabolism in skeletal muscle.
View Study (PubMed)02 Sodium butyrate improves memory function in an Alzheimer's disease mouse model when administered at an advanced stage of disease progression ▸
Research found that sodium butyrate administration can restore memory function and improve cognitive performance even in late-stage neurodegenerative models by elevating histone acetylation.
View Study (PubMed)03 Anti-obesity effect of butyrate links to modulation of gut microbiome and epigenetic regulation of muscular circadian clock ▸
Butyrate supplementation was found to reduce weight gain and enhance fatty acid oxidation by regulating the muscle's circadian clock genes and increasing histone acetylation.
View Study (ScienceDirect)04 Sodium butyrate improves memory and modulates the activity of histone deacetylases in aged rats after the administration of d-galactose ▸
This paper highlights butyrate's ability to reverse memory decline associated with aging and oxidative stress through the modulation of epigenetic markers.
View Study (PubMed)SODIUM BUTYRATE User Reviews & Experiences
*Based on large scale analysis of publicly available user experiences
Users generally view sodium butyrate as a powerful 'biological' tool for gut health and longevity, often reporting significant improvements in brain fog and digestive stability when combined with prebiotics.
SODIUM BUTYRATE Benefits, Dosage & Side Effects
- Metabolic Activation: Enhances mitochondrial biogenesis and fatty acid oxidation, potentially aiding in weight management.
- Neuroprotection: Acts as an HDAC inhibitor to promote histone acetylation, which is linked to improved memory and cognitive clarity.
- Gut Integrity: Strengthens the intestinal barrier and modulates the microbiome, specifically increasing beneficial Firmicutes.
- Epigenetic Regulation: Influences the circadian clock and gene expression related to aging and metabolic health.
- Obesity Prevention: Highly effective in animal models for preventing weight gain despite high-calorie intake.
- Cognitive Recovery: Shows significant promise in reversing symptoms of age-related memory loss and neurodegeneration.
- Insulin Sensitivity: Effectively promotes glucose homeostasis and reduces insulin resistance through skeletal muscle adaptations.
- Synergistic Potential: Works best when combined with dietary fiber (prebiotics) that fuel endogenous butyrate production.
- Clinical Concentration: Often studied in concentrations that achieve significant pan-histone acetylation in target tissues.
- Dietary Supplementation: Frequently taken in capsule form (often Tributyrin or Sodium Butyrate) to bypass early digestion.
- Bioavailability Note: Users often discuss 'scented' vs. 'unscented' versions, noting that the salt form has a distinct, strong odor.
- Fiber Loading: Many users aim for 20-30g of prebiotic fiber to naturally stimulate high internal levels of butyrate.
- Gastrointestinal Odor: The most commonly reported 'side effect' is a strong, cheese-like odor in the supplement and occasionally in breath/sweat.
- Digestive Discomfort: High initial doses may cause mild cramping or changes in bowel habits as the microbiome shifts.
- Electrolyte Balance: As a sodium salt, users with hypertension may need to monitor total daily sodium intake.
- OTC Status: Widely available as an over-the-counter dietary supplement in many regions.
- Formulations: Available in standard sodium butyrate capsules, as well as more shelf-stable or time-released forms like Tributyrin.
Related Compounds
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