SELANK
Last updated: January 6, 2025
For informational purposes only. Not medical advice. Always consult a healthcare professional.
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What Is SELANK?
Selank is a Russian peptide derived from tuftsin with anxiolytic and nootropic properties. It modulates GABA and serotonin systems, reducing anxiety while enhancing cognitive function without sedation or dependency.
This is a peptide. Most peptides are research chemicals requiring reconstitution and subcutaneous injection. Purity and storage conditions matter.
Quick Verdict
Anti-anxiety effects mechanistically similar to benzodiazepines, but without the addiction potential or cognitive blunting. That is a sentence that gets our attention. Selank is derived from the immune peptide tuftsin and acts as a positive allosteric modulator of GABA receptors. The Russian clinical data backs it up. Sentiment is 75/100 across 9 tracked studies.
Evidence Quality
- Human trials: Moderate (Russian clinical data; approved in Russia for anxiety and neurasthenia)
- Animal evidence: Strong (clear anxiolytic effects, modulation of 34 inflammation-related genes)
- Community reports: Strong (consistent reports of reduced anxiety without sedation)
- Key uncertainty: Whether Selank’s immune-modulating effects (34 inflammation genes) have long-term consequences that current short trials have not captured.
What the Research Shows
Selank is studied primarily for anxiety reduction rather than cognitive stimulation. Research shows it induces changes in GABA neurotransmission genes, suggesting a mechanism similar to benzodiazepines. The Semax + Selank combination is the most discussed peptide nootropic stack in community forums, providing both anxiolytic and pro-cognitive effects. Intranasal delivery works within 15-30 minutes in clinical protocols. Unlike benzodiazepines, there are no published reports of physical dependence, which is its primary distinguishing feature relative to pharmaceutical anxiolytics.
Who Should Be Cautious
The immune-modulatory properties mean people with autoimmune conditions should approach with caution. Those on immunosuppressive therapy should consult their physician.
What This Page Cannot Tell You
Like Semax, the clinical evidence is predominantly Russian. Western regulatory bodies have not evaluated Selank, and no Phase III trials exist outside of Russia.
What Experts Say
7. Selank – Non-Sedating Anti-Anxiety • Lowers cortisol and boosts GABA activity • Reduces anxiety and stress without sedation • Supports resilience and mood regulation Dose: 300–600mcg/day Results: 3–5 days for mood shift, 2 weeks for full effect
You can also nebulise peptides for healing of the ears, nose and throat. Plus, this would ensure they'd reach the brain, too. Peptides to nebulise: BPC-157, TA1, TB500/4, Semax, Selank and Cerebrolysin.
N-Acetyl Selank Amidate (20mg) - The Anxiolytic Nootropic Reduces anxiety while enhancing cognition no benzodiazepine side effects. ✓ Anxiolytic effects comparable to benzodiazepines without dependence or memory loss ✓ Regulates BDNF in hippocampus and prefrontal cortex (cognitiv...
Quotes sourced from public posts on X or contributed exclusively to Dopamine Club. Views expressed are those of the original authors.
SELANK Research & Studies
01 Expression of inflammation-related genes in mouse spleen under tuftsin analog Selank ▸
Found significant changes in 34 inflammation-related genes, confirming Selank's immune-regulating role.
View Study (ScienceDirect)02 The temporary dynamics of inflammation-related genes expression under tuftsin analog Selank action ▸
Selank and its Gly-Pro fragment similarly influenced multiple immune-related genes.
View Study (ScienceDirect)03 Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission ▸
Selank induces changes in GABA neurotransmission genes, suggesting a mechanism similar to benzodiazepines.
View Study (Frontiers)04 Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity ▸
Selank functions as a positive allosteric modulator of GABA receptors, offering anxiety relief.
View Study (Institute of Molecular Genetics)05 Physiological Effects of Selank and Its Fragments ▸
Analyzed data on Selank's benefits including anxiety reduction, cognitive enhancement, and immune stimulation.
View Study (Institute of Molecular Genetics)06 Use of Selank to correct measures of integrative brain activity in adult rats from Antenatal Hypoxia ▸
Selank improved sensory attention, learning, and behaviors in rats while restoring serotonin balance.
View Study (Institute of Cell Biophysics)07 The effectiveness of selank in the treatment of adjustment disorder ▸
Selank significantly reduced symptoms of Adjustment Disorder including somatic complaints.
View Study (Ukrainian Scientific Research Institute)08 Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety ▸
Selank works similarly to benzodiazepines and can enhance diazepam's effects under chronic stress.
View Study (Institute of Molecular Genetics)09 Selank and Short Peptides of the Tuftsin Family in the Regulation of Adaptive Behavior in Stress ▸
Evaluated peptide compounds including Selank for emotional and antistress effects.
View Study (V. V. Zakusov Research Institute)SELANK User Reviews & Experiences
Sentiment score computed from aggregated public user reports, forums, and community discussions. Not a clinical measure.
Highly regarded for anxiety relief without sedation or addiction. Users report calm focus and improved stress resilience. Often preferred over semax for anxiety-prone individuals.
SELANK Benefits, Dosage & Side Effects
- Anxiety Reduction: Significant anxiolytic effects without sedation.
- Cognitive Enhancement: Improved memory and focus.
- Stress Resilience: Better ability to handle stressful situations.
- No Dependency: Unlike benzodiazepines, no addiction potential.
- Immune Modulation: May support immune function.
- Fast Acting: Effects often noticed within hours.
- No Tolerance: Maintains effectiveness with continued use.
- Versatile: Benefits both anxiety and cognitive function.
- Typical Range: 250-500mcg intranasally, 1-3 times daily.
- Subcutaneous: Can also be injected subcutaneously.
- Daily Use: Can be used consistently without tolerance.
- Very Well Tolerated: Few side effects reported.
- Nasal Irritation: Minor with intranasal use.
- Fatigue: Some report tiredness at higher doses.
- Excellent Safety: No significant adverse effects documented.
- Research Chemical: Available from peptide suppliers.
- Russian Origin: Approved medication in Russia.
- Nasal Spray: Often sold as premade nasal spray.
Related Compounds
Featured in Protocols
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