REHMANNIA
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What Is REHMANNIA?
Rehmannia, primarily Rehmannia glutinosa, is a traditional Chinese herb that functions as a 'Yin' tonic to support adrenal, kidney, and bone health. It contains bioactives like catalpol and polysaccharides that exhibit significant antioxidant, anti-inflammatory, and neuroprotective properties by modulating signaling pathways like AKT/mTOR and Wnt.
REHMANNIA Research & Studies
01 A Root-Based Combination Supplement Containing Pueraria lobata and Rehmannia glutinosa and Exercise Preserve Bone Mass in Ovariectomized Rats Fed a High-Fat Diet ▸
This study found that Rehmannia extracts combined with exercise significantly preserve bone microarchitecture and decrease bone loss markers in models of postmenopausal osteoporosis.
View Study (PubMed)02 Review of the effects of the traditional Chinese medicine Rehmannia Six Formula on diabetes mellitus and its complications ▸
Research indicates that Rehmannia-based formulas have beneficial effects on blood glucose levels and help prevent diabetic complications like neuropathy and nephropathy.
View Study (PubMed)03 Neuroprotective effects of Rehmannia glutinosa polysaccharide on chronic constant light-induced oxidative stress and autophagic cell death ▸
Polysaccharides from Rehmannia show anti-anxiety and cognitive protection effects by reducing hippocampal neuron damage and oxidative stress.
View Study (PubMed)04 Rehmannia glutinosa exhibits anti-aging effect through maintaining the quiescence and decreasing the senescence of hematopoietic stem cells ▸
The herb demonstrated anti-aging properties by slowing the senescence of stem cells and maintaining their regenerative capacity over time.
View Study (PubMed)05 Study of the Effect of Neutral Polysaccharides from Rehmannia glutinosa on Lifespan of Caenorhabditis elegans ▸
Polysaccharide fractions from Rehmannia were shown to extend lifespan and delay senescence by activating antioxidant enzymatic systems.
View Study (PubMed)REHMANNIA User Reviews & Experiences
*Based on large scale analysis of publicly available user experiences
Users generally view Rehmannia as a potent 'kidney tonic' and anxiolytic, often reporting improved hormone balance and stress resilience, though it is frequently taken in herbal blends rather than in isolation.
REHMANNIA Benefits, Dosage & Side Effects
- Anxiolytic Action: Users report a calming effect similar to mild benzodiazepines when used in specific therapeutic blends.
- Hormonal Support: Reported to help with PMS-related energy crashes and lower back aches associated with the menstrual cycle.
- Adrenal Recovery: Traditionally used and user-validated for combating chronic fatigue and 'burnout' symptoms.
- Kidney Protection: Research and users suggest it supports renal function and protects against oxidative stress in the kidneys.
- Bone Health: Highly effective in animal models for preventing bone mineral density loss during menopause.
- Anti-Aging: Validated through multiple studies showing lifespan extension in simple organisms and stem cell protection in mammals.
- Preparation Matters: The effects of 'Prepared' (steamed) Rehmannia differ from 'Raw' Rehmannia, particularly regarding its impact on digestion and glucose metabolism.
- Synergistic Potential: Effectiveness is often enhanced when paired with other herbs like Ginseng (Liangyi paste) or Pueraria lobata.
- Standardized Extracts: Clinical animal models often utilize doses between 100mg/kg to 400mg/kg body weight.
- Root Powder: Common carp studies used a 4% prepared root powder concentration in diet for microbiota benefits.
- Traditional Formulations: Often consumed as part of the 'Rehmannia Six Formula' (Liuwei Dihuang Wan) rather than a standalone extract.
- Hairy Root Cultures: Laboratory production focuses on optimizing catalpol content, which can reach up to 0.7% dry weight.
- Digestive Sensitivity: Crude or raw forms can sometimes cause loose stools or digestive upset if not properly prepared.
- Sedation: While beneficial for anxiety, some users report excessive tiredness when taken during the day.
- Hypoglycemia Risk: Due to its blood-sugar-lowering effects, it may interact with diabetic medications.
- Microbiome Shifts: Long-term use can significantly alter intestinal flora, potentially increasing beneficial Firmicutes.
- Herbal Sourcing: Widely available in traditional Chinese pharmacies as either 'Sheng Di Huang' (Raw) or 'Shu Di Huang' (Prepared).
- Supplement Formats: Commonly found in 'Kidney Support' or 'Adrenal Support' capsules and complex liquid tinctures.
Related Compounds
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