OLEIC ACID

Meta-analysis of 31 RCTs involving 1,634 subjects found that oleic acid supplementation significantly reduced C-reactive protein (CRP) levels, indicating anti-inflammatory benefits, though it did not significantly affect other inflammatory markers like TNF or IL-6.

Oleic acid infusion reduced adipose tissue lipolysis and improved insulin sensitivity in dairy cows during the periparturient period, suggesting beneficial effects on metabolic regulation and energy balance.

Oleic acid supplementation reduced amyloid-beta levels and BACE enzyme activity in Alzheimer's disease models, decreased amyloid plaques, and increased non-amyloidogenic APP processing, suggesting neuroprotective effects.

Oleic acid demonstrated potent pancreatic lipase inhibitory activity with an IC50 of 11.7 µg/mL and significantly suppressed fat digestion and absorption in rats, suggesting potential for weight management applications.

Dietary oleic acid supplementation increased the proportion of slow-twitch type 1 and oxidative type 2X muscle fibers in mice, suggesting potential benefits for endurance and metabolic muscle characteristics.

Nitro-oleic acid, a metabolite of oleic acid, was found to regulate macrophage differentiation and modulate immune responses, demonstrating anti-inflammatory properties in bone marrow-derived cells.

Study used oleic acid to induce hepatic steatosis models, demonstrating its role in fatty liver research and establishing that interventions targeting oxidative stress pathways can ameliorate oleic acid-induced liver damage.

Research utilized oleic acid to model lipid metabolism disorders in hepatocytes, demonstrating that interventions activating AMPK-mTOR pathways can reverse oleic acid-induced metabolic disturbances.