MYRICETIN
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What Is MYRICETIN?
Myricetin is a flavonoid compound found in berries, red wine, and various fruits and vegetables that exhibits potent antioxidant and anti-inflammatory properties. It works through multiple mechanisms including inhibition of various enzymes (CYP2C9, CYP2D6, cathepsin K, gastric H+/K+-ATPase), modulation of PI3K/AKT and Nrf2 signaling pathways, and enhancement of neurotrophic factors like BDNF and NGF. Research indicates potential benefits for metabolic disorders, cognitive function, cancer prevention, and inflammatory conditions.
MYRICETIN Research & Studies
01 Efficacy of Myricetin Supplementation on Glucose and Lipid Metabolism: A Systematic Review and Meta-Analysis of In Vivo Mice Studies ▸
Meta-analysis of mouse studies showed myricetin supplementation significantly improved glucose metabolism and lipid profiles in metabolic disease models, demonstrating potential anti-diabetic effects through insulin sensitivity enhancement.
View Study (PubMed)02 Myricetin improves cognitive function in SAMP8 mice and upregulates brain-derived neurotrophic factor and nerve growth factor ▸
Daily myricetin intake normalized cognitive dysfunction in aging mouse models by increasing BDNF and NGF levels and enhancing CREB phosphorylation, suggesting neuroprotective benefits.
View Study (PubMed)03 Therapeutic potential of multifunctional myricetin for treatment of type 2 diabetes mellitus ▸
Review demonstrates myricetin's multiple anti-diabetic mechanisms including inhibiting glucose absorption, enhancing insulin secretion as a possible GLP-1 receptor agonist, and protecting endothelial cells from hyperglycemia-induced oxidative stress.
View Study (PubMed)04 Hypoglycemic activity and mechanisms of myricetin ▸
Four-week administration of myricetin (50-200 mg/kg) in diabetic rats dose-dependently reduced blood glucose and insulin while protecting pancreatic tissue from apoptosis through regulation of Bax and Bcl-2 genes.
View Study (PubMed)05 Unveiling myricetin's pharmacological potency: A comprehensive exploration of the molecular pathways with special focus on PI3K/AKT and Nrf2 signaling ▸
Comprehensive review revealed myricetin's therapeutic effects operate through PI3K/AKT and Nrf2 pathways, demonstrating antioxidant, anticancer, anti-inflammatory, antiviral, antidiabetic, and neuroprotective properties.
View Study (PubMed)06 Myricetin bioactive effects: moving from preclinical evidence to potential clinical applications ▸
Systematic review of preclinical evidence shows myricetin exhibits multiple bioactive effects including anti-inflammatory, antioxidant, anticancer, and metabolic benefits, supporting its potential as a therapeutic supplement.
View Study (PubMed)07 Flavonoid Myricetin as Potent Anticancer Agent: A Possibility towards Development of Potential Anticancer Nutraceuticals ▸
Review highlights myricetin's anticancer properties through multiple mechanisms, suggesting strong potential for development as an anticancer nutraceutical with applications in preventing and managing various cancer types.
View Study (PubMed)08 Myricetin ameliorates the symptoms of collagen-induced arthritis in mice by inhibiting cathepsin K activity ▸
Myricetin (25 mg/kg daily) directly inhibited cathepsin K enzyme activity and demonstrated positive effects in reducing arthritic symptoms in mouse models of collagen-induced arthritis.
View Study (PubMed)MYRICETIN User Reviews & Experiences
*Based on large scale analysis of publicly available user experiences
Limited User feedback exists about myricetin specifically, with most mentions occurring in broader supplement discussions. Users show interest in it as a COMT inhibitor and include it in complex supplement regimens, but there is insufficient user feedback to establish clear consensus on effectiveness or side effects.
MYRICETIN Benefits, Dosage & Side Effects
- Metabolic Support: Research demonstrates significant improvements in glucose metabolism and insulin sensitivity in diabetic models
- Cognitive Enhancement: Studies show upregulation of BDNF and NGF with improvements in memory and cognitive function in aging models
- Anti-inflammatory Action: Exhibits cathepsin K inhibition and reduces inflammatory markers in arthritis and other inflammatory conditions
- Antioxidant Protection: Provides cellular protection against oxidative stress through Nrf2 pathway activation and free radical scavenging
- Dose-Response Relationship: Studies show effectiveness at 50-200 mg/kg in animal models with dose-dependent improvements
- Multiple Mechanisms: Works through various pathways including enzyme inhibition, gene expression modulation, and receptor activation
- Metabolic Benefits: Meta-analysis confirms significant effects on glucose and lipid profiles in metabolic disease models
- Neuroprotection: Demonstrated cognitive improvements through neurotrophic factor enhancement and CREB phosphorylation
- Animal Studies: Most effective doses range from 25-200 mg/kg body weight in rodent models
- Human Equivalence: Direct human dosing not well established; extrapolation from animal studies suggests moderate supplementation
- COMT Inhibition: Users mention interest in myricetin for COMT inhibition but specific effective doses not reported
- Supplement Combinations: Often included in multi-supplement regimens but isolated dosing recommendations limited
- Drug Interactions: Inhibits CYP2C9, CYP2D6, and P-glycoprotein, potentially affecting metabolism of various medications
- Bioavailability Effects: May significantly increase bioavailability of co-administered drugs like carvedilol by 52-85%
- Digestive Concerns: Some users report potential constipation when combined with other supplements in complex regimens
- Safety Profile: Generally well-tolerated in studies but long-term human safety data limited
- Natural Sources: Found in berries, red wine, fruits, and vegetables; available as dietary supplement
- Supplement Forms: Available as isolated compound or in combination products with other flavonoids
- Research Status: Extensively studied in preclinical models but human clinical trial data remains limited
Related Compounds
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