Melanotan 1

What Is Melanotan 1?

Peptide

Melanotan 1 (Afamelanotide) is a synthetic analog of alpha-MSH that stimulates melanin production, causing skin darkening without sun exposure. It's FDA-approved for certain conditions and provides photoprotection for those with light sensitivity.

Melanotan 1 Research & Studies

01 In vitro evaluation of Poly(d,l-lactide-co-glycolide) polymer-based implants containing the α-melanocyte stimulating hormone analog, Melanotan-I ▸

Study examined release patterns of Melanotan-I from biodegradable PLGA implants, observing three-phase release.

View Study (ScienceDirect)
02 An unhealthy glow? A review of melanotan use and associated clinical outcomes ▸

Literature review on Melanotan I and II effects, identifying minor and serious adverse effects including toxidrome and melanoma.

View Study (ScienceDirect)
03 Controlled-Release Delivery System for the α-MSH Analog Melanotan-I Using Poloxamer 407 ▸

Researchers developed controlled-release formulations using poloxamer 407 with additives for sustained delivery.

View Study (ScienceDirect)
04 In vitro characterization and in vivo release profile of a poly (d,l-lactide-co-glycolide)-based implant delivery system for the α-MSH analog, Melanotan-I ▸

Researchers developed biodegradable copolymer implants for sustained Melanotan-I delivery, demonstrating steady release over one month.

View Study (ScienceDirect)
05 Effect of MELANOTAN®, [Nle4, D-Phe7]-α-MSH, on melanin synthesis in humans with MC1R variant alleles ▸

Study found MELANOTAN® significantly increased melanin, especially in those with MC1R genetic variants.

View Study (ScienceDirect)

Melanotan 1 User Reviews & Experiences

65% Positive

*Based on large scale analysis of publicly available user experiences

Users seeking tanning without sun exposure report good results. Slower acting than MT-2 but considered safer. FDA approval for EPP lends legitimacy.

Melanotan 1 Benefits, Dosage & Side Effects

Effects
  • Skin Darkening: Gradual, natural-looking tan without UV exposure.
  • Photoprotection: Increased protection against sun damage.
  • Melanin Production: Stimulates melanocytes to produce melanin.
  • Minimal Sexual Effects: Unlike MT-2, minimal libido effects.
Effectiveness
  • Slower Than MT-2: Takes longer to produce visible tanning.
  • More Natural: Produces more gradual, natural-looking results.
  • FDA Approved: Scenesse approved for erythropoietic protoporphyria.
Dosage & Administration
  • Typical Range: 0.5-1mg subcutaneously daily.
  • Loading Phase: Often 1mg daily until desired tan achieved.
  • Maintenance: Reduced frequency once tan established.
Side Effects
  • Nausea: Common, especially initially.
  • Facial Flushing: Temporary redness after injection.
  • Mole Darkening: Existing moles may darken.
  • Safer Profile: Fewer side effects than MT-2.
Availability & Sourcing
  • Prescription: FDA-approved as Scenesse for EPP.
  • Research Chemical: Also available from peptide suppliers.
  • Higher Cost: Generally more expensive than MT-2.

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