MATRINE
Tried MATRINE? Be part of the collective knowledge. Share your experience - your insights help others on their journey.
What Is MATRINE?
Matrine is a tetracyclic quinolizidine alkaloid extracted from the medicinal plant Sophora flavescens that exhibits anti-inflammatory, neuroprotective, and anti-proliferative properties. It works by modulating multiple cellular signaling pathways including TLR4/NF-κB/MAPK, NLRP3 inflammasome, and AMPK pathways. Traditionally used in Chinese medicine, matrine has been studied for its effects on liver diseases, inflammation, neurological disorders, and cancer.
MATRINE Research & Studies
01 Matrine exerts its neuroprotective effects by modulating multiple neuronal pathways ▸
Comprehensive review demonstrating that matrine protects neurons by crossing the blood-brain barrier and modulating multiple signaling pathways, showing therapeutic potential for Multiple Sclerosis, Alzheimer's disease, and other neurological disorders.
View Study (PubMed)02 Matrine Exerts Pharmacological Effects Through Multiple Signaling Pathways: A Comprehensive Review ▸
Detailed review showing matrine has broad pharmacological activities including anti-tumor, anti-inflammatory, analgesic, anti-fibrotic, anti-viral effects through activation or inhibition of key molecules in cellular signaling pathways, with therapeutic effects in various tumors, cardiopathy, and CNS inflammation.
View Study (PubMed)03 Preventive effects of matrine on LPS-induced inflammation in RAW 264.7 cells and intestinal damage in mice through the TLR4/NF-κB/MAPK pathway ▸
Study demonstrates matrine's anti-inflammatory properties by inhibiting the TLR4/NF-κB/MAPK pathway, showing protective effects against LPS-induced intestinal damage and inflammation in both cell and mouse models.
View Study (PubMed)04 Matrine suppresses NLRP3 inflammasome activation via regulating PTPN2/JNK/SREBP2 pathway in sepsis ▸
Research showing matrine suppresses abnormal NLRP3 inflammasome activation in sepsis through the PTPN2/JNK/SREBP2 pathway, demonstrating anti-inflammatory properties in life-threatening dysregulated host responses to infection.
View Study (PubMed)05 Oxymatrine relieves non-alcoholic fatty liver disease by promoting sirtuin 1/adenosine 5'-monophosphate-activated protein kinase pathway and peroxisome proliferator activated receptor alpha-mediated hepatic fatty acid oxidation ▸
Study demonstrates that oxymatrine (a derivative of matrine) has protective effects in NAFLD by promoting the SIRT1/AMPK pathway and enhancing hepatic fatty acid oxidation, showing therapeutic potential for liver disease.
View Study (PubMed)06 Matrine inhibits vascular smooth muscle cell proliferation by modulating the expression of cell cycle regulatory genes ▸
Research showing matrine inhibits vascular smooth muscle cell proliferation in a dose-dependent manner by promoting G1 arrest through up-regulation of p53, p21, and p27, demonstrating potential cardiovascular benefits.
View Study (PubMed)07 Effects of oxymatrine and matrine on left ventricular contractility using pressure-volume relationship analysis in anesthetized rats ▸
Study using advanced cardiac analysis showed that both oxymatrine and matrine significantly improved load-independent cardiac parameters, increased cardiac efficiency, and improved mechanoenergetics, suggesting cardiovascular benefits.
View Study (PubMed)08 Matrine induces ferroptosis in cervical cancer through activation of piezo1 channel ▸
Research demonstrates matrine's anti-cancer properties by inducing ferroptosis (a form of cell death) in cervical cancer cells through activation of the piezo1 channel, showing potential therapeutic utility in cancer treatment.
View Study (PubMed)MATRINE User Reviews & Experiences
*Based on large scale analysis of publicly available user experiences
User experiences are limited and primarily negative, with one individual reporting anxiety and derealization from 100mg dose, expressing concern about potential 5-AR inhibition. The user data shows no positive user testimonials for matrine itself, with discussions focused on other supplements entirely.
MATRINE Benefits, Dosage & Side Effects
- Anti-inflammatory Action: Demonstrated to reduce inflammation through multiple pathways including TLR4/NF-κB/MAPK and NLRP3 inflammasome suppression
- Neuroprotection: Crosses blood-brain barrier and modulates neuronal pathways, showing potential for neurodegenerative diseases
- Cardiovascular Support: Improves cardiac contractility and mechanoenergetics in animal studies
- Cell Cycle Modulation: Inhibits abnormal cell proliferation through regulation of p53, p21, p27 and other cell cycle regulatory genes
- Research-Backed: Extensive preclinical research demonstrates anti-inflammatory, neuroprotective, and anti-proliferative effects across multiple disease models
- Multiple Pathways: Works through various cellular signaling mechanisms rather than a single target, potentially explaining broad pharmacological activities
- Traditional Use: Long history of use in Traditional Chinese Medicine for liver conditions and inflammation
- Limited Human Data: Most evidence comes from cell culture and animal studies; human clinical trial data remains limited
- Research Doses: Animal studies typically use 50-200 mg/kg, though human equivalent doses not well established
- User Experience: One Reddit user reported negative effects at 100mg dose in humans
- Extract Standardization: Commercial products often use 98% matrine extracts from Sophora flavescens
- Traditional Preparation: Historically consumed as part of whole plant preparations rather than isolated compound
- Psychological Effects: User report of anxiety and derealization at 100mg dose
- 5-AR Inhibition Concern: Potential 5-alpha reductase inhibitory activity suspected in parent plant, though not confirmed for isolated matrine
- Kappa-Opioid Activity: Known kappa-opioid receptor activity may contribute to dysphoric effects
- Safety Profile: Research papers generally note matrine as well-tolerated in animal studies, but human safety data limited
- Supplement Form: Available as isolated extract (98% matrine) from supplement companies like reputable suppliers
- Plant Source: Derived from Sophora flavescens (Ku Shen) and related Sophora species used in Traditional Chinese Medicine
- Research Chemical: Primarily used in research settings; consumer supplement use appears minimal based on user discussions
Related Compounds
Community Reviews
Share your experience with MATRINE and help others make informed decisions.
Write a Review
Sign in to leave a review