LL-37
Last updated: January 6, 2025
For informational purposes only. Not medical advice. Always consult a healthcare professional.
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What Is LL-37?
LL-37 is a human antimicrobial peptide (cathelicidin) that plays a crucial role in innate immunity. It has antibacterial, antiviral, and antifungal properties, and also modulates inflammation and wound healing.
This is a peptide. Most peptides are research chemicals requiring reconstitution and subcutaneous injection. Purity and storage conditions matter.
LL-37 Research & Studies
01 The structure of the antimicrobial human cathelicidin LL-37 shows oligomerization and channel formation in the presence of membrane mimics ▸
LL-37 creates a narrow tetrameric channel in bacterial cell walls, causing cell wall damage and cell death.
View Study (Springer Nature)02 Antimicrobial cathelicidin peptide LL-37 inhibits the pyroptosis of macrophages and improves the survival of polybacterial septic mice ▸
LL-37 improves survival in septic mice by suppressing macrophage pyroptosis and inflammatory cytokine production.
View Study (Oxford Academic)03 LL-37: Cathelicidin-related antimicrobial peptide with pleiotropic activity ▸
LL-37 exhibits broad-spectrum antibiotic activity with chemotactic and immunomodulatory properties.
View Study (ScienceDirect)04 The Human Cathelicidin Antimicrobial Peptide LL-37 and Mimics are Potential Anticancer Drugs ▸
LL-37 and its fragments demonstrate potential anticancer effects across various cancer cell lines.
View Study (Frontiers)05 A comprehensive summary of LL-37, the factotum human cathelicidin peptide ▸
LL-37 exhibits pleiotropic antibacterial, antifungal, antiviral, and chemotactic properties with immunostimulatory effects.
View Study (ScienceDirect)06 The human cathelicidin peptide LL-37 inhibits pancreatic cancer growth by suppressing autophagy and reprogramming of the tumor immune microenvironment ▸
LL-37 inhibits pancreatic cancer growth through autophagy suppression and immune microenvironment reprogramming.
View Study (Frontiers)LL-37 User Reviews & Experiences
Sentiment score computed from aggregated public user reports, forums, and community discussions. Not a clinical measure.
Used primarily for immune support and infection management. Users with chronic infections report benefits. More common in clinical and biohacking contexts.
LL-37 Benefits, Dosage & Side Effects
- Antimicrobial: Active against bacteria, viruses, and fungi.
- Immune Modulation: Helps regulate immune response.
- Wound Healing: Promotes tissue repair and regeneration.
- Biofilm Disruption: Can help break down bacterial biofilms.
- Broad Spectrum: Active against many types of pathogens.
- Immune Support: May help with chronic or recurring infections.
- Synergy: Sometimes combined with other antimicrobial peptides.
- Typical Range: 100-500mcg subcutaneously.
- Frequency: Often daily or every other day during acute use.
- Duration: Cycles vary depending on indication.
- Injection Site Reactions: Redness and irritation common.
- Inflammatory Response: May initially increase inflammation.
- Limited Safety Data: Long-term use not well studied.
- Research Chemical: Available from peptide suppliers.
- Specialized Use: Not as common as other peptides.
- Quality Critical: Purity important for injectable use.
Related Compounds
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