LAMINARIN
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What Is LAMINARIN?
Laminarin is a polysaccharide extracted from brown seaweeds (Laminaria species) composed primarily of β-1,3-glucan chains. It functions as a prebiotic that modulates gut microbiota, exhibits immunomodulatory and anti-inflammatory properties, and enhances intestinal barrier function. Primarily studied in animal nutrition, particularly for improving growth performance and gastrointestinal health in weaned pigs and poultry.
LAMINARIN Research & Studies
01 Laminarin-rich extract improves growth performance, small intestinal morphology, gene expression of nutrient transporters and the large intestinal microbial composition of piglets during the critical post-weaning period ▸
Supplementation with 300 ppm laminarin improved growth performance, enhanced small intestinal morphology and nutrient transporter expression, and favorably modulated gut microbiota composition in weaned piglets.
View Study (PubMed)02 Effect of a Laminarin Rich Macroalgal Extract on the Caecal and Colonic Microbiota in the Post-Weaned Pig ▸
Dietary laminarin at 300 ppm increased feed intake, growth rate, and body weight while reducing pathogenic Enterobacteriaceae and increasing beneficial Prevotella bacteria in the gut of weaned pigs.
View Study (PubMed)03 Effects of dietary supplementation with a laminarin-rich extract on the growth performance and gastrointestinal health in broilers ▸
Broiler chickens supplemented with 300 ppm laminarin showed improved body weight, daily gain, and feed intake, along with enhanced expression of nutrient transporters and improved intestinal integrity markers.
View Study (PubMed)04 Dietary supplementation of laminarin improves the reproductive performance of sows and the growth of suckling piglets ▸
Laminarin supplementation in sow diets enhanced reproductive performance, improved antioxidant capacity, reduced inflammatory responses, and promoted beneficial gut microbiota homeostasis in both sows and their offspring.
View Study (PubMed)05 Laminarin favorably modulates gut microbiota in mice fed a high-fat diet ▸
Laminarin supplementation slowed weight gain in high-fat diet-fed mice and induced favorable changes in gut microbial community composition, demonstrating potential prebiotic anti-obesity effects.
View Study (PubMed)06 Dietary administration of laminarin improves the growth performance and immune responses in Epinephelus coioides ▸
Laminarin supplementation enhanced growth performance, improved immunological parameters, and upregulated immune-related gene expression in grouper fish, demonstrating immunostimulatory effects.
View Study (PubMed)07 Feeding Marine Polysaccharides to Alleviate the Negative Effects Associated with Weaning in Pigs ▸
This review highlights laminarin's prebiotic, antibacterial, anti-oxidant, and immunomodulatory activities, positioning it as a promising natural alternative to antibiotics for managing post-weaning stress in pigs.
View Study (PubMed)08 Seaweed Components as Potential Modulators of the Gut Microbiota ▸
Laminarin and other seaweed polysaccharides demonstrate prebiotic potential by enhancing beneficial bacterial populations and promoting short-chain fatty acid production, which supports gastrointestinal health and immune function.
View Study (PubMed)LAMINARIN User Reviews & Experiences
*Based on large scale analysis of publicly available user experiences
There is insufficient Reddit user experience data available to assess sentiment. The available research focuses exclusively on animal models (pigs, poultry, fish) with no substantial human user reports or testimonials.
LAMINARIN Benefits, Dosage & Side Effects
- Gut Microbiota Modulation: Consistently increases beneficial bacteria (Lactobacillus, Prevotella) while reducing pathogenic species (E. coli, Enterobacteriaceae) across animal studies
- Intestinal Barrier Enhancement: Improves intestinal morphology, increases villus height, and upregulates tight junction proteins (ZO-1, claudin-1, occludin)
- Immune Function Support: Enhances immune parameters including secretory IgA, cytokine production (IL-6, TNF-α), and immune-related gene expression
- Antioxidant Activity: Increases antioxidant enzyme activities (glutathione peroxidase, superoxide dismutase, catalase) and reduces oxidative stress markers
- Growth Performance: Demonstrates consistent improvements in weight gain, feed conversion ratio, and daily feed intake across multiple animal species at optimal doses
- Dose-Dependent Response: Effectiveness appears optimal at 300-400 ppm (mg/kg) in pig and poultry diets, with higher doses not necessarily providing additional benefits
- Prebiotic Activity: Functions effectively as a prebiotic by selectively promoting beneficial gut bacteria and producing short-chain fatty acids
- Application Specificity: Most evidence supports use during critical stress periods (weaning, dietary transitions) rather than continuous supplementation
- Optimal Range: 300-400 mg/kg (ppm) of feed demonstrated best results in pig and poultry studies for growth and gut health improvements
- Lower Dose Effects: 100-200 mg/kg shows modest benefits but less consistent than higher doses
- Species Variation: Fish studies used 5-15 g/kg with benefits observed, suggesting dose requirements may vary by species and application
- Duration: Benefits typically observed after 14-35 days of supplementation in animal feeding trials
- Minimal Adverse Effects: Animal studies report no significant adverse effects at studied doses up to 800 mg/kg
- Weight Gain Rebound: In obesity studies, weight gain resumed after cessation of laminarin supplementation, suggesting effects may not persist
- Dose Ceiling: Very high doses (>800 mg/kg) do not provide additional benefits and may have diminishing returns
- Human Data Lacking: No human safety or side effect data available as research is limited to animal models
- Research-Only Status: Laminarin is primarily available as a research compound for animal nutrition studies, not as a consumer supplement
- Extraction Source: Commercially extracted from brown seaweeds (Laminaria hyperborea, L. digitata) with purity typically around 65% laminarin content
- Agricultural Applications: Mainly used in animal feed industry as a natural growth promoter and antibiotic alternative, not marketed for human consumption
Related Compounds
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