IBUTAMOREN (MK-677)
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What Is IBUTAMOREN (MK-677)?
Ibutamoren (MK-677) is an orally active growth hormone secretagogue that stimulates the release of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) by mimicking the action of ghrelin at the ghrelin receptor. Unlike exogenous GH, it promotes pulsatile GH release while maintaining normal feedback mechanisms and does not suppress endogenous testosterone production. Originally developed for treating muscle wasting, osteoporosis, and growth hormone deficiency, it has gained attention for potential applications in body composition improvement, recovery enhancement, and sleep quality optimization.
IBUTAMOREN (MK-677) Research & Studies
01 Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man ▸
Seven-day treatment with MK-677 significantly improved sleep quality in both young and older adults, increasing REM sleep duration and sleep efficiency through growth hormone pathway modulation.
View Study (PubMed)02 Two-month treatment of obese subjects with the oral growth hormone (GH) secretagogue MK-677 increases GH secretion, fat-free mass, and energy expenditure ▸
Eight weeks of MK-677 treatment (25mg daily) in obese males significantly increased GH secretion, fat-free mass by approximately 1.1kg, and basal metabolic rate without affecting fat mass.
View Study (PubMed)03 MK-677, an orally active growth hormone secretagogue, reverses diet-induced catabolism ▸
MK-677 (25mg daily) completely reversed diet-induced negative nitrogen balance in healthy volunteers, demonstrating significant anti-catabolic effects during caloric restriction.
View Study (PubMed)04 Oral administration of the growth hormone secretagogue MK-677 increases markers of bone turnover in healthy and functionally impaired elderly adults ▸
MK-677 administration significantly increased bone formation markers (osteocalcin and bone-specific alkaline phosphatase) and bone resorption markers in elderly subjects, suggesting potential benefits for bone health.
View Study (PubMed)05 Effects of a 7-day treatment with a novel, orally active, growth hormone (GH) secretagogue, MK-677, on 24-hour GH profiles, insulin-like growth factor I, and adrenocortical function in normal young men ▸
Seven days of MK-677 treatment increased 24-hour GH secretion by 50-89%, elevated IGF-I levels by 52-79%, and increased GH pulse frequency without significantly affecting cortisol levels.
View Study (PubMed)06 The effects of MK-0677, an oral growth hormone secretagogue, in patients with hip fracture ▸
While MK-677 successfully elevated IGF-I levels in elderly hip fracture patients, it did not significantly improve functional recovery or reduce length of hospital stay compared to placebo.
View Study (PubMed)07 LGD-4033 and MK-677 use impacts body composition, circulating biomarkers, and skeletal muscle androgenic hormone and receptor content: A case report ▸
Combined use of LGD-4033 and MK-677 increased lean mass and fat mass but negatively impacted bone health, liver enzymes, lipid profiles, and suppressed testosterone and FSH levels.
View Study (PubMed)08 Growth hormone secretagogue MK-677: no clinical effect on AD progression in a randomized trial ▸
Despite successfully raising IGF-I levels, 12-month treatment with MK-677 showed no clinical benefit in slowing Alzheimer's disease progression in a randomized controlled trial.
View Study (PubMed)IBUTAMOREN (MK-677) User Reviews & Experiences
*Based on large scale analysis of publicly available user experiences
User sentiment is genuinely mixed, with most users reporting positive effects on appetite, recovery, and sleep quality, but expressing concerns about potential side effects including elevated blood glucose, water retention, and long-term safety. Many users are cautious about dosing and recommend careful monitoring while acknowledging the compound's effectiveness for specific goals.
IBUTAMOREN (MK-677) Benefits, Dosage & Side Effects
- Increased Appetite: Users consistently report significant increases in appetite and hunger, making it easier to maintain caloric surplus for muscle building goals
- Enhanced Sleep Quality: Multiple reports of improved sleep depth and quality, with better recovery and REM sleep duration
- Improved Recovery: Users note faster recovery from training and enhanced muscle fullness, attributed to increased GH and IGF-1 levels
- Body Composition Changes: Reports of increased lean mass and water retention, creating a fuller appearance though not always accompanied by fat loss
- GH/IGF-1 Elevation: Research consistently demonstrates 40-89% increases in IGF-1 levels and significant GH secretion enhancement at doses of 10-25mg daily
- Muscle Preservation: Strong evidence for anti-catabolic effects during caloric restriction, with complete reversal of diet-induced nitrogen loss in clinical studies
- Sleep Benefits: Well-documented improvements in sleep quality and REM sleep duration across multiple studies in both young and elderly populations
- Limited Fat Loss: Despite increasing GH levels, studies show minimal direct fat loss effects, with body composition changes primarily reflecting increased lean mass and water retention
- Standard Dose: Most users and studies utilize 10-25mg daily, with 25mg being the most common research dose
- Starting Dose: Users frequently recommend starting at 10mg to assess tolerance before potentially increasing to 20-25mg
- Timing: Typically taken once daily at bedtime to align with natural GH secretion patterns and leverage sleep-enhancing effects
- Cycle Length: Research protocols range from 7 days to several months, with users commonly running 8-12 week cycles followed by breaks
- Elevated Blood Glucose: Research and users report increased fasting blood glucose and potential insulin sensitivity issues, particularly concerning for metabolic health
- Water Retention: Common reports of increased fluid retention and edema, contributing to temporary weight gain
- Increased Hunger: While beneficial for bulking, the significant appetite stimulation can be problematic for those not seeking to gain weight
- Hormonal Concerns: When stacked with SARMs, potential negative impacts on testosterone, liver enzymes, and lipid profiles have been documented
- Legal Status: Not approved for human use by FDA, classified as an unapproved drug and prohibited substance by WADA and DoD
- Market Access: Despite legal restrictions, widely available online marketed as 'research chemical' or incorrectly as dietary supplement, raising quality and safety concerns
- Quality Control: FDA has issued warning letters to companies selling MK-677, highlighting concerns about product purity and accurate labeling in unregulated markets
Related Compounds
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