Huperzine A
What Is Huperzine A?
Huperzine A is a natural compound extracted from Chinese club moss that inhibits acetylcholinesterase, increasing acetylcholine levels in the brain. It enhances memory, learning, and may have neuroprotective properties.
Huperzine A Research & Studies
01 Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer's Disease ▸
Reviews how Huperzine A, an alkaloid from club moss, interacts with molecular pathways including Wnt signaling, synaptic mechanisms, and amyloid-β accumulation to provide neuroprotection.
View Study (PubMed)02 Ginkgolides and Huperzine A for complementary treatment of Alzheimer's disease ▸
Highlights positive outcomes from plant-based therapies including Huperzine A in improving cognitive function and neuropsychiatric symptoms in Alzheimer's patients.
View Study (PubMed)03 Delineating biosynthesis of Huperzine A, A plant-derived medicine for the treatment of Alzheimer's disease ▸
Explores alternative production methods for Huperzine A, including biosynthesis and pathway engineering, to address supply constraints from slow-growing plant sources.
View Study (PubMed)04 Disease-Modifying Activity of Huperzine A on Alzheimer's Disease: Evidence from Preclinical Studies on Rodent Models ▸
Animal studies demonstrate Huperzine A's potential to improve memory and reduce harmful brain substances, though findings require further confirmation.
View Study (PubMed)05 The effects of Huperzine A on dementia and mild cognitive impairment: An overview of systematic reviews ▸
Meta-analysis finding Huperzine A may benefit Alzheimer's patients with cognitive function but lacks sufficient evidence for other cognitive impairments.
View Study (PubMed)06 Neuroprotective effect of huperzine-A against cadmium chloride-induced Huntington's disease in Drosophila melanogaster model ▸
Laboratory studies suggest Huperzine A reduces neurodegenerative symptoms in cell and fly models, indicating promise for Huntington's disease.
View Study (ScienceDirect)07 Huperzine A injection ameliorates motor and cognitive abnormalities via regulating multiple pathways in a murine model of Parkinson's disease ▸
Injectable Huperzine A improved motor and cognitive function in mice with Parkinson's disease by reducing inflammation and oxidative stress.
View Study (ScienceDirect)Huperzine A User Reviews & Experiences
*Based on large scale analysis of publicly available user experiences
Users report improved memory and mental clarity. Popular in nootropic stacks, particularly for cholinergic enhancement. Long half-life requires careful dosing.
Huperzine A Benefits, Dosage & Side Effects
- Memory Enhancement: Improved recall and memory formation.
- Focus: Better concentration and attention.
- Neuroprotection: May protect against cognitive decline.
- Lucid Dreaming: Some users report more vivid dreams.
- Potent AChE Inhibitor: More selective than donepezil.
- Long-Lasting: Effects persist due to long half-life.
- Synergy: Works well with choline sources.
- Typical Range: 50-200mcg once or twice daily.
- Cycling: Recommended due to long half-life (cycle 2-4 weeks on/off).
- Start Low: Begin with 50mcg to assess response.
- Cholinergic Effects: Nausea, headache, muscle twitching possible.
- GI Issues: Digestive discomfort in some users.
- Accumulation: Can build up due to long half-life.
- Not with AChE Inhibitors: Avoid combining with donepezil or similar drugs.
- Supplement: Available in most nootropic and supplement stores.
- Various Forms: Capsules, tablets, and powder.
- Affordable: Generally inexpensive.
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