HCG
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What Is HCG?
Human Chorionic Gonadotropin (hCG) is a glycoprotein hormone that mimics luteinizing hormone (LH), primarily functioning to support the corpus luteum and progesterone production during early pregnancy. In clinical and off-label settings, it is used to maintain testicular function during hormone replacement, treat infertility, and occasionally as an adjunct in weight management protocols.
HCG Research & Studies
01 Human Chorionic Gonadotropin: The Pregnancy Hormone and More ▸
This review explores hCG's role beyond pregnancy, highlighting its function in steroidogenesis and its clinical application in treating reproductive disorders and certain malignancies.
View Study (PubMed)02 hCG: Biological Functions and Clinical Applications ▸
The paper details how hCG acts through LH receptors to promote steroid production and its essential role in maintaining early gestational health.
View Study (PubMed)03 Human Chorionic Gonadotropin - StatPearls ▸
A comprehensive clinical overview of hCG's use in distinguishing pregnancy types, monitoring pregnancy loss, and its application in in-vitro fertilization care.
View Study (PubMed)HCG User Reviews & Experiences
*Based on large scale analysis of publicly available user experiences
Users generally report high satisfaction with hCG for maintaining testicular volume and libido during TRT, though some find managing estrogen levels to be a significant challenge.
HCG Benefits, Dosage & Side Effects
- Testicular Maintenance: Prevents or reverses testicular atrophy by mimicking LH signaling to the Leydig cells
- Libido Enhancement: Many users report improved sexual drive and increased ejaculate volume during use
- Steroidogenesis Support: Stimulates the natural production of testosterone and other neurosteroids even when external hormones are present
- Fertility Preservation: Highly effective at maintaining sperm production for men on testosterone replacement therapy
- Quick Onset: Users often report feeling 'fuller' or seeing changes in testicular size within 1-2 weeks of starting a protocol
- Mood Stabilization: Reported to fix the 'flatness' or lack of emotion some men feel when using exogenous testosterone alone
- TRT Adjunct: Commonly reported doses range from 250 IU to 500 IU administered two to three times per week
- Monotherapy/PCT: Higher doses of 1,000 IU to 2,000 IU every other day are sometimes used for short durations to jumpstart natural production
- Subcutaneous Injection: Most users prefer shallow injections into abdominal fat using insulin syringes for ease and steady absorption
- Estrogen Spikes: hCG can cause a significant increase in aromatization, leading to sensitive nipples or water retention
- Gynecomastia: Risks of breast tissue development if estrogen is not monitored and managed with an aromatase inhibitor
- Acne: Increased hormonal fluctuations can lead to skin breakouts on the back, shoulders, or face
- Prescription Status: Available legally via prescription for infertility or as part of a medically supervised TRT program
- Storage Requirements: Lyophilized powder is stable at room temperature but must be refrigerated once reconstituted with bacteriostatic water
Related Compounds
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