GSK-971086
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What Is GSK-971086?
GSK2881078 (frequently identified in research as GSK-971086 precursor series) is a nonsteroidal selective androgen receptor modulator (SARM) designed to target the androgen receptor with high affinity and tissue selectivity. It is engineered to promote anabolic activity in skeletal muscle while minimizing androgenic effects on reproductive tissues, primarily intended to treat muscle wasting and functional limitations associated with chronic illness.
GSK-971086 Research & Studies
01 GSK2881078, a SARM, Produces Dose-Dependent Increases in Lean Mass in Healthy Older Men and Women ▸
This study demonstrated that the compound significantly increases lean body mass in a dose-dependent manner in both older men and postmenopausal women over a 28-to-56-day period
View Study (PubMed)02 Safety, pharmacokinetics and pharmacological effects of the selective androgen receptor modulator, GSK2881078, in healthy men and postmenopausal women ▸
Research clinical trials found the compound to be generally well-tolerated with a long half-life, showing evidence of muscle-building potential without significant prostate stimulation
View Study (PubMed)GSK-971086 User Reviews & Experiences
*Based on large scale analysis of publicly available user experiences
Users view it as a potent and 'clean' anabolic agent for lean mass, but interest is tempered by its limited availability compared to more common SARMs like Ostarine or Ligandrol.
GSK-971086 Benefits, Dosage & Side Effects
- Lean Mass Accrual: Clinical data shows a significant increase in leg lean mass and total lean body mass.
- Tissue Selectivity: Designed to stimulate muscle growth while remaining 'prostate-sparing' in men.
- Anabolic Potency: Users and researchers note high binding affinity to androgen receptors compared to earlier generation SARMs.
- Long Half-Life: The compound remains active in the system for an extended period, allowing for stable blood levels.
- Dose-Dependency: Effectiveness for muscle growth is directly tied to dosage, with higher yields at the top end of tested ranges.
- Gender Response: While effective in both, postmenopausal women showed a higher sensitivity to the lean-mass-building effects at lower doses than men.
- Strength Gains: Users report consistent, steady strength increases rather than rapid water-weight gain.
- Chronic Illness Potential: Specifically noted for its ability to reverse muscle weakness in aging and acute illness populations.
- Clinical Range (Men): Research utilized doses ranging from 0.05 mg to 4.0 mg daily for healthy male subjects.
- Clinical Range (Women): Doses for postmenopausal women were typically lower, often capped at 0.5 mg to 1.0 mg to evaluate safety.
- User Consensus: Anecdotal reports often suggest starting at the lowest research-backed dose due to the compound's high potency and long half-life.
- Cycle Length: Most clinical evaluations and user protocols span 4 to 8 weeks to assess mass changes.
- Testosterone Suppression: Like most SARMs, it can cause a dose-dependent reduction in total testosterone and SHBG levels.
- HDL Reduction: Significant decreases in high-density lipoprotein (good cholesterol) have been observed during clinical cycles.
- ALT Elevation: Some instances of transient increases in liver enzymes (ALT) have been reported, requiring monitoring.
- Virilization Risks: In women, higher doses carry a theoretical risk of androgenic side effects such as acne or hair growth, though clinical trials aimed to minimize this.
- Research Status: Currently categorized as an investigational drug; it is not FDA-approved for human consumption outside of clinical trials.
- Sourcing Difficulty: Less common on the gray market compared to LGD-4033 or MK-2866, often requiring specialized research chemical suppliers.
- Legal Status: Sold strictly for 'research purposes' and is prohibited by WADA for use in competitive sports.
Related Compounds
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