GONADORELIN
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What Is GONADORELIN?
Gonadorelin is a synthetic decapeptide and a pharmaceutical-grade analogue of the naturally occurring gonadotropin-releasing hormone (GnRH). It works by stimulating the anterior pituitary gland to release luteinizing hormone (LH) and follicle-stimulating hormone (FSH), making it a primary tool for diagnosing pituitary dysfunction and inducing ovulation or spermatogenesis.
GONADORELIN Research & Studies
01 Ganirelix ▸
This study examines a GnRH antagonist derivative used to block LH surges during IVF, achieving a significant pregnancy rate of over 40% with daily subcutaneous administration.
View Study (PubMed)02 Modulatory effects of gonadorelin on GABA-induced depolarization and GABA-activated current in rat spinal ganglion neurons ▸
Researchers found that gonadorelin exerts an inhibitory effect on GABA-induced currents in sensory neurons, suggesting potential roles in neurological modulation beyond reproduction.
View Study (PubMed)03 Effect of gonadorelin, lecirelin, and buserelin on LH surge, ovulation, and progesterone in cattle ▸
Comparative clinical trials demonstrated that gonadorelin effectively triggers an LH surge and subsequent ovulation within specific windows following administration.
View Study (PubMed)04 Effects of gonadorelin on gonadotropin expression, plasma sex steroid concentrations and ovarian follicle dynamics in mature tambaqui ▸
This study highlights gonadorelin's ability to induce ovulation and strip spawning in species that typically fail to spawn in captive environments by modulating molecular mechanisms.
View Study (PubMed)05 Gonadorelin and erythropoiesis ▸
Early research suggests a link between gonadorelin administration and the stimulation of red blood cell production, potentially through indirect hormonal pathways.
View Study (PubMed)GONADORELIN User Reviews & Experiences
*Based on large scale analysis of publicly available user experiences
Users are largely divided; while it is effectively used in clinical fertility settings, fitness enthusiasts often find it inferior to HCG for testosterone recovery due to its very short half-life and the requirement for frequent dosing.
GONADORELIN Benefits, Dosage & Side Effects
- LH/FSH Stimulation: Rapidly triggers the release of gonadotropins to support testosterone or estrogen production.
- Ovulation Induction: Effectively induces the ripening and release of eggs in various mammalian species.
- Neuro-Modulation: Influences GABAergic signaling in sensory neurons, indicating central nervous system activity.
- Short Half-Life: The drug's efficacy is limited by a very short metabolic life, often requiring pulsatile or very frequent administration.
- Clinical Utility: Highly effective for diagnostic testing of the hypothalamic-pituitary-gonadal axis.
- TRT Recovery: Viewed by many as less effective than HCG for maintaining testicular volume because it does not provide the steady stimulation needed.
- Subcutaneous Injection: Typically administered at 0.25 mg/day in fertility protocols to suppress premature LH surges.
- Pulsatile Delivery: In specific clinical cases, doses are delivered via an automated pump every 90-120 minutes to mimic natural GnRH release.
- Diagnostic Dose: Often administered as a single 100 mcg bolus to evaluate pituitary response.
- Injection Site Reactions: Local redness, swelling, or pain at the site of subcutaneous administration is common.
- Systemic Symptoms: Some users report malaise, headache, nausea, and fatigue following treatment.
- Hormonal Fluctuations: Potential for mood swings or hot flashes as hormone levels spike and fall rapidly.
- Prescription Only: Strictly regulated as a medical pharmaceutical, typically sourced via fertility clinics or HRT specialists.
- Veterinary Use: Widely available and commonly used in livestock management for estrus synchronization.
Related Compounds
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