GINKGOLIDE B
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What Is GINKGOLIDE B?
Ginkgolide B is a terpene lactone compound extracted from Ginkgo biloba leaves, standardized in extracts like EGb 761. It works primarily as a platelet-activating factor (PAF) antagonist, improves cerebral blood flow, and exhibits neuroprotective and antioxidant properties. It is used for cognitive enhancement, vascular disorders, and neuroprotection in aging and neurodegenerative conditions.
GINKGOLIDE B Research & Studies
01 Human pharmacokinetics of ginkgo terpene lactones and impact of carboxylation in blood on their platelet-activating factor antagonistic activity ▸
Ginkgolides A and B showed high systemic exposure with oral bioavailability mostly >100%, terminal half-lives of 6-13 hours, and platelet-activating factor antagonistic activity that is reduced upon carboxylation in blood.
View Study (Nature)02 Ginkgolide B production in cultured cells derived from Ginkgo biloba L. leaves ▸
Cell suspension cultures derived from Ginkgo biloba leaves successfully produced ginkgolide B, with maximum production reached by day 13 of subculture using optimized medium conditions.
View Study (Springer)03 Cognitive Impairment and Nootropic Drugs: Mechanism of Action and Spectrum of Effects ▸
Ginkgo biloba extracts act through multiple mechanisms including neurotransmitter modulation, cerebral vasodilation, antioxidant activity, and neuroprotection, showing efficacy in cognitive dysfunction from aging and dementia.
View Study (Springer)GINKGOLIDE B User Reviews & Experiences
*Based on large scale analysis of publicly available user experiences
Users consistently report that Ginkgo biloba improves alertness, concentration, focus, and memory, with beneficial effects on cerebral circulation and neuroprotection. While not extensively discussed as a standalone supplement, it is frequently included in effective cognitive enhancement stacks with positive outcomes.
GINKGOLIDE B Benefits, Dosage & Side Effects
- Cognitive Enhancement: Users report improved alertness, concentration, focus, and memory recall
- Cerebral Circulation: Increases blood flow to the brain, improving oxygen and glucose availability to neurons
- Neuroprotection: Provides antioxidant activity and protects against brain cell degeneration
- Anxiety Reduction: Acts as a monoamine oxidase inhibitor, potentially boosting dopamine and reducing anxiety
- Memory and Learning: Effective for improving cognitive function in aging, dementia, and neurodegenerative conditions through enhanced cerebral blood flow
- Standardization Matters: EGb 761 extract standardized to 24% flavonoids and 6% terpene lactones (including ginkgolides) shows consistent therapeutic effects
- Bioavailability Variation: Ginkgolides A and B demonstrate high oral bioavailability (>100%), while ginkgolides C and J show lower bioavailability (6-15%)
- Long-term Use: Historical use spanning millennia in traditional Chinese medicine, with modern research supporting efficacy for vascular and cognitive disorders
- Standard Extract: EGb 761 extract standardized to 24% flavone glycosides and 6% terpene lactones is the research-supported formulation
- Clinical Doses: Typically 120-240mg of standardized extract daily, divided into 2-3 doses
- Bioactive Compounds: Ginkgolides A and B are the primary active terpene lactones with highest systemic exposure
- Terminal Half-life: Ginkgolides have half-lives ranging from 4-13 hours depending on formulation and administration route
- Carboxylation Effects: Ginkgolides undergo carboxylation in blood which reduces their platelet-activating factor antagonistic activity
- Drug Interactions: May interact with anticoagulants and other medications due to platelet-activating factor antagonism
- Generally Well-Tolerated: Most users report minimal side effects when using standardized extracts at recommended doses
- Individual Variation: Response varies based on genetic factors and baseline cognitive status
- Widely Available: Ginkgo biloba extracts are among the most commonly used herbal supplements worldwide
- Standardization Important: Look for EGb 761 or similar standardized extracts rather than non-standardized products
- Quality Concerns: Avoid purchasing from major retailers due to commingling and counterfeit issues; prefer direct manufacturers or reputable retailers like online retailers
Related Compounds
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