FAD
Tried FAD? Be part of the collective knowledge. Share your experience - your insights help others on their journey.
What Is FAD?
Flavin Adenine Dinucleotide (FAD) is a critical redox-active coenzyme derived from riboflavin (vitamin B2) that functions as a prosthetic group for various flavoproteins. It plays a central role in the mitochondrial electron transport chain and the Krebs cycle, facilitating essential energy production and metabolic homeostasis through cellular oxidation-reduction reactions.
FAD Research & Studies
01 The role of NAD+ metabolism and its modulation of mitochondria in aging and disease ▸
This review explores how essential cofactors like NAD+ and related redox molecules support mitochondrial health and homeostatic components like mitophagy to combat age-related decline.
View Study (PubMed)02 Emerging strategies, applications and challenges of targeting NAD+ in the clinic ▸
Researchers discuss the diverse roles of pyridine and flavin-related nucleotides in signaling pathways, epigenetic regulation, and energy homeostasis as clinical targets for aging.
View Study (PubMed)03 Effect of Nicotinamide Adenine Dinucleotide on Heart Failure Caused by Ischemic Cardiomyopathy: A Randomized, Placebo-Controlled Trial ▸
Sub-study analysis indicates that boosting redox cofactors improves cardiac bioenergetics and clinical outcomes like ejection fraction in patients with heart failure.
View Study (PubMed)FAD User Reviews & Experiences
*Based on large scale analysis of publicly available user experiences
Users generally view FAD and its precursors as highly effective for sustaining mitochondrial energy, though many note it is often best used as part of a broader B-vitamin or NAD-boosting stack.
FAD Benefits, Dosage & Side Effects
- Physical Energy: Users report sustained improvements in daily stamina and a reduction in general lethargy.
- Metabolic Efficiency: Enhanced processing of macronutrients due to its role as a cofactor in the Krebs cycle.
- Mitochondrial Health: Potential long-term support for cellular respiration and reduction of oxidative stress.
- Cognitive Clarity: Secondary reports of reduced 'brain fog' associated with improved systemic energy levels.
- Bioavailability: Evidence suggests that active forms like FAD may be more effective than simple riboflavin for individuals with specific genetic mutations (e.g., MTHFR).
- Syntropic Benefits: Most effective when paired with other mitochondrial supports like CoQ10 or NAD+ precursors.
- Onset: Users typically report feeling metabolic changes within 1-2 weeks of consistent supplementation.
- Clinical Support: Growing clinical interest in using redox cofactors to treat cardiac and metabolic dysfunctions.
- Active Forms: Supplements providing 50mg to 100mg of riboflavin-5-phosphate or FAD are commonly used to ensure cofactor availability.
- Stacked Dose: Lower doses (10-25mg) are frequent when integrated into a high-quality B-complex.
- Precursor Loading: Some users prefer high-dose riboflavin (up to 400mg) under medical supervision for specific conditions like migraines.
- Chromaturia: A harmless but bright yellow-orange discoloration of urine is the most frequently reported effect.
- Digestive Discomfort: Rare reports of mild nausea if taken on an empty stomach.
- Overstimulation: Occasional reports of difficulty sleeping if taken too late in the evening due to increased ATP production.
- Direct Sourcing: FAD is less common as a standalone supplement than riboflavin or R5P but is available from specialty chemical and longevity vendors.
- Regulatory Status: Generally recognized as safe (GRAS) when sold as a form of Vitamin B2 in the United States.
Related Compounds
Community Reviews
Share your experience with FAD and help others make informed decisions.
Write a Review
Sign in to leave a review