ERGOTHIONEINE
Tried ERGOTHIONEINE? Be part of the collective knowledge. Share your experience - your insights help others on their journey.
What Is ERGOTHIONEINE?
Ergothioneine is a naturally occurring sulfur-containing amino acid and potent antioxidant that is primarily obtained through dietary sources like mushrooms and absorbed via the highly specific OCTN1 (ETT) transporter. It acts as a cytoprotective agent by accumulating in tissues subject to high oxidative stress, where it helps protect DNA, proteins, and lipids from damage while supporting mitochondrial function.
ERGOTHIONEINE Research & Studies
01 Ergothioneine promotes longevity and healthy aging in male mice ▸
Long-term oral supplementation in mice significantly extended lifespan and reduced age-related declines in movement velocity, cognitive function, and hippocampal neurogenesis.
View Study (PubMed)02 Ergothioneine: A Stress Vitamin with Antiaging, Vascular, and Neuroprotective Roles? ▸
This review analyzes ergothioneine's role as a potential 'longevity vitamin' that protects against oxidative stress-induced damage in vascular and neural systems.
View Study (PubMed)03 Ergothioneine for cognitive health, longevity and healthy ageing: where are we now? ▸
A comprehensive review of the current evidence supporting ergothioneine's ability to support brain health and mitigate cognitive decline in aging populations.
View Study (PubMed)04 Ergothioneine as a functional nutraceutical: Mechanisms, bioavailability, and therapeutic implications ▸
Researchers explore the compound's potent anti-inflammatory and cytoprotective properties, highlighting its unique transport mechanism into human cells.
View Study (PubMed)ERGOTHIONEINE User Reviews & Experiences
*Based on large scale analysis of publicly available user experiences
Users overwhelmingly view Ergothioneine as a 'foundational' longevity supplement with high interest in its neuroprotective benefits and lack of acute side effects.
ERGOTHIONEINE Benefits, Dosage & Side Effects
- Neuroprotection: Users and research report improved cognitive clarity and a reduction in 'brain fog' over long-term use.
- Mitochondrial Support: Enhances cellular energy efficiency and protects against oxidative damage to DNA.
- Telomere Preservation: Clinical findings suggest it may reduce the rate of telomere shortening under periods of oxidative stress.
- Systemic Anti-inflammation: Suppresses age-related increases in inflammatory biomarkers and promotes immune balance.
- Cumulative Benefits: Users note that effects are subtle and build over months rather than providing an immediate 'rush.'
- Cognitive Maintenance: Highly effective in animal models for rescuing memory deficits and promoting hippocampal neurogenesis.
- Biomarker Improvement: Research indicates significant suppression of markers for kidney stress and metabolic decline.
- Transport Specificity: Exceptionally bioavailable due to the body's dedicated OCTN1 transporter, ensuring high cellular absorption.
- Standard Maintenance: 5mg to 10mg daily is the most common dosage for general healthy aging.
- Therapeutic Range: Some users and studies explore up to 25mg-30mg per day for targeted cognitive support.
- Body Weight Scaling: Clinical studies in mice utilize 4-5 mg/kg, which translates to moderate human doses to achieve longevity effects.
- Mushrooms as Source: Dietary intake of 100g of mushrooms periodically is suggested as a natural alternative to purified supplements.
- Minimal Reported: Most users report zero acute side effects even with daily long-term administration.
- Digestive Comfort: Unlike some antioxidants, it is generally well-tolerated by the stomach.
- Unknown Long-term in Humans: While mouse data is positive, some users express caution regarding the lack of multi-decade human clinical trials.
- Increasing Market: Widely available as a fermented or synthetic ingredient (e.g., ErgoActive) in high-end longevity brands.
- Dietary Sources: Highest concentrations are found in specialty mushrooms like Porcini, Oyster, and Shiitake.
Related Compounds
Community Reviews
Share your experience with ERGOTHIONEINE and help others make informed decisions.
Write a Review
Sign in to leave a review