Donepezil
What Is Donepezil?
Donepezil is an acetylcholinesterase inhibitor FDA-approved for Alzheimer's disease. By preventing acetylcholine breakdown, it enhances cholinergic transmission and cognitive function. Some use it off-label for cognitive enhancement.
Donepezil Research & Studies
01 Donepezil for dementia due to Alzheimer's disease ▸
Evaluates donepezil's modest benefits in cognitive function and daily living activities over 12-24 weeks, noting higher doses produce more adverse events.
View Study (PubMed)02 Clinical efficacy and safety of donepezil in the treatment of Alzheimer's disease in Chinese patients ▸
Reviews donepezil effectiveness in Chinese populations, finding it generally safe with potential impacts on disease biomarkers.
View Study (PubMed)03 Efficacy and safety of donepezil, galantamine, and rivastigmine for the treatment of Alzheimer's disease ▸
Systematic review comparing three cholinesterase inhibitors through comprehensive database searches to evaluate their therapeutic effectiveness.
View Study (PubMed)04 Impact of Donepezil and Memantine on Behavioral and Psychological Symptoms of Alzheimer Disease ▸
Study of 85 moderate Alzheimer's patients found both medications significantly reduced behavioral symptoms, with good tolerability.
View Study (PubMed)05 Donepezil in the treatment of ischemic stroke: Review and future perspective ▸
Explores donepezil's potential neuroprotective effects in ischemic stroke, noting preclinical promise but limited clinical evidence.
View Study (PubMed)Donepezil User Reviews & Experiences
*Based on large scale analysis of publicly available user experiences
Mixed reports for cognitive enhancement in healthy individuals. More consistently beneficial for those with cognitive impairment. Side effects can be significant.
Donepezil Benefits, Dosage & Side Effects
- Improved Memory: Enhanced recall and memory consolidation.
- Increased Attention: Better focus and sustained attention.
- Vivid Dreams: Intensified dream activity commonly reported.
- Modest Enhancement in Healthy: Effects more pronounced in those with deficits.
- Best for Impairment: Most effective for treating cognitive decline.
- Variable in Healthy: Benefits less consistent in cognitively healthy individuals.
- Long Half-Life: Reaches steady state after several weeks.
- Medical Dose: 5-10mg daily for Alzheimer's treatment.
- Off-Label Use: Often 2.5-5mg for cognitive enhancement.
- Once Daily: Long half-life allows single daily dosing.
- Cholinergic Effects: Nausea, diarrhea, and muscle cramps common.
- Sleep Disturbances: Insomnia and vivid dreams reported.
- Bradycardia: Can slow heart rate; caution with cardiac conditions.
- GI Issues: Digestive problems frequent, especially initially.
- Prescription Required: FDA-approved medication requiring prescription.
- Generic Available: Affordable generic versions widely available.
- International Pharmacies: May be obtained from overseas sources.
Community Reviews
Share your experience with Donepezil and help others make informed decisions.
Write a Review
Sign in to leave a review