CYANIDIN
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What Is CYANIDIN?
Cyanidin-3-O-glucoside (C3G) is a naturally occurring anthocyanin compound found abundantly in berries, black rice, purple corn, and blood oranges. It functions as a potent antioxidant and anti-inflammatory agent that modulates lipid metabolism, enhances mitochondrial function, and improves endothelial health. C3G has demonstrated therapeutic potential for obesity-related metabolic disorders, cardiovascular health, and insulin sensitivity through multiple cellular pathways including SIRT1/NF-κB signaling and NLRP3 inflammasome regulation.
CYANIDIN Research & Studies
01 Recent advances on cyanidin-3-O-glucoside in preventing obesity-related metabolic disorders: A comprehensive review ▸
C3G demonstrates significant efficacy in combating obesity by regulating lipid metabolism, increasing fatty acid oxidation, reducing lipid accumulation, and enhancing energy expenditure through brown adipose tissue activation and mitochondrial biogenesis.
View Study (PubMed)02 Effectiveness of 'Moro' Blood Orange Extract on Weight Loss in Overweight Adults - A Randomized Double-Blind Placebo-Controlled Study ▸
After 6 months, participants taking blood orange extract rich in C3G showed significantly greater reductions in body mass (4.2% vs 2.2%), BMI, and hip circumference compared to placebo.
View Study (PubMed)03 Cyanidin-3-O-Glucoside Supplementation Ameliorates Metabolic Insulin Resistance via Restoration of Nitric Oxide-Mediated Endothelial Insulin Transport ▸
C3G supplementation improves metabolic insulin resistance by restoring endothelial insulin transport through nitric oxide pathways, decreasing exogenous insulin requirements in skeletal muscle.
View Study (PubMed)04 Cyanidin-3-O-β-glucoside inactivates NLRP3 inflammasome and alleviates alcoholic steatohepatitis via SirT1/NF-κB signaling pathway ▸
C3G alleviates alcoholic liver injury by inactivating NLRP3 inflammasome and modulating SirT1/NF-κB signaling pathways, demonstrating hepatoprotective effects.
View Study (PubMed)05 Anthocyanins and their metabolites promote white adipose tissue beiging by regulating mitochondria thermogenesis and dynamics ▸
C3G and its metabolites promote browning of white adipose tissue and enhance mitochondrial thermogenesis, leading to decreased body weight gain and fat deposition on high-fat diets.
View Study (PubMed)06 Cyanidin-3-O-Glucoside Alleviates Alcoholic Liver Injury via Modulating Gut Microbiota and Metabolites in Mice ▸
C3G effectively ameliorates liver pathology and function while inhibiting lipid accumulation by modulating gut microbiota composition and metabolite profiles.
View Study (PubMed)07 Cyanidin-3-rutinoside from Mori Fructus ameliorates dyslipidemia via modulating gut microbiota and lipid metabolism pathway ▸
Cyanidin compounds improve dyslipidemia through beneficial modulation of gut microbiota and regulation of lipid metabolism pathways, suggesting therapeutic potential for cardiovascular disease prevention.
View Study (PubMed)08 Elderberries as a potential supplement to improve vascular function in a SARS-CoV-2 environment ▸
Elderberries high in C3G demonstrate vascular protective properties and prevention of cardiovascular disease-related complications, with potential benefits for endothelial dysfunction.
View Study (PubMed)CYANIDIN User Reviews & Experiences
*Based on large scale analysis of publicly available user experiences
User feedback discussions show limited direct user experience with C3G specifically, though users discuss it positively as a thermogenic supplement when combined with other compounds like black ginger. The broader supplement community shows cautious optimism about natural compounds but remains concerned about sourcing quality and long-term safety of various supplements.
CYANIDIN Benefits, Dosage & Side Effects
- Weight Management: Users report taking C3G for thermogenic effects, particularly when stacked with black ginger for fat loss and metabolic benefits
- Metabolic Support: Research demonstrates significant improvements in lipid metabolism, insulin sensitivity, and energy expenditure through multiple cellular pathways
- Cardiovascular Protection: Studies show endothelial function improvement and vascular protection through antioxidant and anti-inflammatory mechanisms
- Liver Health: Demonstrated hepatoprotective effects against alcohol-induced injury and fat accumulation through gut microbiota modulation
- Clinical Evidence: Randomized controlled trials show 4.2% body mass reduction over 6 months with blood orange extract containing C3G versus 2.2% with placebo
- Dose-Dependent Response: Research indicates C3G effectiveness varies with dosage, with standardized extracts from blood oranges showing consistent metabolic benefits
- Synergistic Effects: Works through multiple pathways including mitochondrial biogenesis, brown adipose tissue activation, and gut microbiota modulation for comprehensive metabolic support
- Limited Long-Term Data: While short to medium-term studies (6-12 months) show benefits, extensive long-term human data beyond this timeframe is limited
- Blood Orange Extract: Clinical trials used standardized Moro blood orange extract daily for 6 months showing significant weight loss and metabolic improvements
- Research Doses: Animal studies typically use 100 mg/kg/day C3G, though human equivalent doses require conversion and clinical validation
- Natural Sources: C3G is abundant in blackberries, elderberries, black rice, and blood oranges as dietary sources
- Timing Considerations: Users report taking C3G-containing supplements in the morning, sometimes combined with other thermogenic compounds
- Generally Well-Tolerated: Research studies report minimal adverse effects with C3G supplementation in clinical trials
- Potential Interactions: Users note theoretical interactions with curcumin and other supplements that affect drug-metabolizing enzymes
- Quality Concerns: Broader supplement community expresses concerns about heavy metal contamination in plant-based supplements, emphasizing need for third-party testing
- Limited Safety Data: Long-term safety data beyond 6-12 months in humans is not extensively documented in available literature
- Natural Food Sources: Readily available through dietary sources including berries, blood oranges, black rice, and purple corn
- Supplement Forms: Available as standardized blood orange extracts (like Moro cultivar) and standalone C3G supplements from various vendors including specialty retailers
- Quality Verification: Users recommend sourcing from reputable brands with third-party testing due to concerns about contamination in plant-based supplements
Related Compounds
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