CORDYCEPIN
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What Is CORDYCEPIN?
Cordycepin (3'-deoxyadenosine) is a natural nucleoside analog derived from Cordyceps militaris fungus that structurally resembles adenosine. It works by modulating multiple cellular pathways including adenosine receptor signaling, oxidative stress response (Keap1/Nrf2/HO-1), and inflammatory cascades, demonstrating anti-inflammatory, antioxidant, neuroprotective, and metabolic regulatory effects.
CORDYCEPIN Research & Studies
01 Cordycepin combined with antioxidant effects improves fatigue caused by excessive exercise ▸
Cordycepin enhanced exercise endurance, increased liver and muscle glycogen content, decreased fatigue metabolites (lactic acid, creatine kinase), and improved learning/memory deficits from over-exercise by modulating the Keap1/Nrf2/HO-1 signaling pathway and BDNF expression.
View Study (PubMed)02 Anti-inflammatory effects of cordycepin: A review ▸
Comprehensive review demonstrating cordycepin's anti-inflammatory properties through multiple mechanisms including modulation of NF-κB, MAPK pathways, and cytokine production, with therapeutic potential for inflammatory diseases.
View Study (PubMed)03 Antidepressant-like effects of cordycepin in a mice model of chronic unpredictable mild stress ▸
Cordycepin demonstrated antidepressant-like effects in stress-induced animal models, suggesting potential mood-regulating and stress-response modulating properties.
View Study (PubMed)04 Structural and pharmacological insights into cordycepin for neoplasms and metabolic disorders ▸
Review highlighting cordycepin's significant therapeutic potential in alleviating hyperlipidemia, regulating glucose metabolism, and demonstrating anti-tumor effects through multiple mechanisms including apoptosis induction and immune modulation.
View Study (PubMed)CORDYCEPIN User Reviews & Experiences
*Based on large scale analysis of publicly available user experiences
User experiences with cordycepin are limited in the available data, with research showing promising anti-fatigue, anti-inflammatory, and metabolic benefits, but insufficient Reddit user feedback to establish strong consensus on subjective effects, tolerability, or practical efficacy.
CORDYCEPIN Benefits, Dosage & Side Effects
- Anti-Fatigue: Enhances exercise endurance and reduces physical fatigue by increasing glycogen stores and reducing lactate accumulation
- Antioxidant Activity: Increases superoxide dismutase activity and reduces oxidative stress markers like MDA through Nrf2 pathway activation
- Anti-Inflammatory: Modulates inflammatory pathways including NF-κB and MAPK, reducing pro-inflammatory cytokine production
- Neuroprotective: Improves learning and memory deficits from stress/over-exercise by enhancing BDNF levels and neurotransmitter regulation
- Exercise Performance: Demonstrated significant improvements in exercise endurance, glycogen restoration, and reduction of fatigue biomarkers in animal studies
- Metabolic Regulation: Shows therapeutic potential for hyperlipidemia and glucose metabolism disorders through multiple molecular mechanisms
- Stress Response: Exhibits antidepressant-like effects in chronic stress models, suggesting mood-regulating properties
- Bioavailability Concerns: Research indicates strategies to enhance bioavailability may be necessary for optimal therapeutic effects
- Research Doses: Animal studies typically use doses scaled appropriately to body weight, with human equivalent doses requiring careful conversion
- Timing Considerations: Anti-fatigue effects suggest potential benefits when taken before exercise or during periods of high physical demand
- Combination Approaches: Often studied in combination with other Cordyceps compounds or antioxidants for enhanced effects
- Duration: Effects on fatigue, metabolism, and inflammation may require sustained supplementation for optimal benefits
- Limited Human Data: Most safety data comes from animal studies; comprehensive human side effect profiles are not well-established
- Adenosine-Related Effects: As an adenosine analog, potential effects on cardiovascular and nervous system should be considered
- Metabolic Impact: Blood sugar and lipid-regulating effects require monitoring in those with metabolic conditions
- General Tolerance: Research suggests good tolerance in animal models, but long-term human safety data is limited
- Natural Source: Derived from Cordyceps militaris fungus, available through various supplement manufacturers
- Quality Variability: Cordycepin content can vary significantly between products; standardized extracts are preferable for consistent dosing
- Regulatory Status: Generally available as a dietary supplement, though quality control and purity standards vary by manufacturer
Related Compounds
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