BUTYRATE
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What Is BUTYRATE?
Butyrate is a short-chain fatty acid (SCFA) produced by the gut microbiota through the fermentation of dietary fiber, serving as the primary energy source for colonocytes. It acts as a histone deacetylase (HDAC) inhibitor and signals through G-protein coupled receptors to regulate immune responses, maintain intestinal barrier integrity, and stabilize the gut-brain axis.
BUTYRATE Research & Studies
01 Effects of short-chain fatty acid-butyrate supplementation on expression of circadian-clock genes, sleep quality, and inflammation in patients with active ulcerative colitis: a double-blind randomized controlled trial ▸
This study found that sodium butyrate supplementation significantly improved sleep quality and reduced inflammatory markers like hs-CRP and fecal calprotectin in patients with ulcerative colitis.
View Study (PubMed)02 Efficacy of sodium butyrate adjunct therapy in shigellosis: a randomized, double-blind, placebo-controlled clinical trial ▸
Researchers demonstrated that butyrate enemas improved clinical and histological features of shigellosis by inducing antimicrobial peptides in the intestinal mucosa.
View Study (PubMed)03 Calcium butyrate efficacy in pediatric irritable bowel syndrome: Randomized placebo-controlled multiomics-based clinical trial ▸
A 2025 clinical trial investigating the efficacy of calcium butyrate in managing pediatric IBS symptoms through microbiome modulation.
View Study (PubMed)04 Effect of Supplementation of a Butyrate-Based Formula in Individuals with Liver Steatosis and Metabolic Syndrome: A Randomized Double-Blind Placebo-Controlled Clinical Trial ▸
A clinical trial evaluating butyrate's role in improving liver health and metabolic parameters in patients with fatty liver disease.
View Study (PubMed)BUTYRATE User Reviews & Experiences
*Based on large scale analysis of publicly available user experiences
The majority of users view butyrate as a foundational 'biohacking' supplement for gut-driven systemic health, though some report paradoxical effects on sleep and fatigue depending on timing.
BUTYRATE Benefits, Dosage & Side Effects
- Inflammation Reduction: Users and studies report a significant drop in systemic inflammatory markers and improved gut-barrier function.
- Metabolic Signaling: Supplementation is linked to increased GLP-1 levels, which may assist in appetite suppression and weight management.
- Circadian Modulation: Research indicates butyrate influences clock gene expression, potentially regulating sleep-wake cycles.
- Gut-Brain Communication: Users report improvements in 'brain fog' and mental clarity when gut inflammation is addressed.
- Gastrointestinal Relief: Highly effective for active ulcerative colitis and IBS, reducing disease severity and abdominal pain.
- Secondary Metabolic Benefits: Shows promise in reducing liver steatosis and supporting weight loss protocols when paired with diet.
- Bioavailability Issues: Users note that oral forms must bypass the stomach (tributyrin or enteric coating) to reach the colon effectively.
- Psychological Adjuvant: Recent evidence suggests it may alleviate psychological symptoms like anxiety and depression associated with gut dysbiosis.
- Standard Oral Dose: Clinical trials often utilize doses ranging from 600mg to 1,200mg of sodium or calcium butyrate daily.
- Intervention Loading: Some users report taking up to 1.2g in the morning to combat bloating and improve digestion.
- Topical/Local Application: In acute infectious cases like shigellosis, 80 mM enemas have been used effectively for localized treatment.
- Fiber-First Approach: Many users prefer 'butyrogenic' diets (inulin, resistant starch) over pills to naturally boost levels.
- Diurnal Fatigue: Some users report feeling 'unbelievably tired' when taking butyrate in the morning.
- Sleep Disruption: Paradoxical insomnia or reduced sleep quality reported by some users when taken in the evening.
- Initial Bloating: Introduction of butyrate or prebiotics can cause temporary gas or 'hunger pangs' as the microbiome shifts.
- Odor: Sodium butyrate supplements are notorious for a strong, 'cheesy' or rancid smell that many users find unpleasant.
- Over the Counter: Widely available as a dietary supplement in Sodium, Calcium, and Magnesium salt forms.
- Tributyrin: Increasingly sold as a more bioavailable liquid fat form that survives digestion better than salts.
Related Compounds
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