BAICALEIN
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What Is BAICALEIN?
Baicalein is a bioactive flavonoid compound extracted from the roots of Scutellaria baicalensis (Chinese skullcap). It demonstrates neuroprotective, anti-inflammatory, and antioxidant properties by modulating multiple cellular pathways including NLRP3 inflammasome, Nrf2/HO-1, and MAPK signaling cascades. Research indicates potential therapeutic applications in neurodegenerative diseases, anxiety, depression, and cognitive function through reduction of neuroinflammation and oxidative stress.
BAICALEIN Research & Studies
01 Mitigating neurodegenerative diseases: the protective influence of baicalin and baicalein through neuroinflammation regulation ▸
Baicalein and baicalin show protective effects in animal models of neurodegenerative diseases by inhibiting pro-inflammatory cytokines, suppressing microglial activation, and regulating inflammatory signaling cascades including TLR4, MAPK, and NLRP3 inflammasome pathways.
View Study (PubMed)02 Neuroprotective effects of baicalin and baicalein on the central nervous system and the underlying mechanisms ▸
Multiple studies demonstrate that baicalein effectively reduces severity of depression, stroke, and CNS degenerative disorders by exerting antioxidant and anti-inflammatory effects, regulating programmed cell death, and reducing mitochondrial dysfunction.
View Study (PubMed)03 The effects of baicalin in depression: preclinical evidence construction based on meta-analysis ▸
Meta-analysis of preclinical studies shows baicalin significantly improves depressive symptoms in animal models, increasing sucrose preference and reducing immobility in forced swim and tail suspension tests, demonstrating antidepressant potential.
View Study (PubMed)04 Baicalein: Multiple Pharmacological Activities, Pharmacokinetics, and Clinical Trials ▸
Comprehensive review demonstrates baicalein's therapeutic potential across multiple conditions including neurodegenerative diseases and cardiovascular health through modulation of oxidative stress, inflammatory responses, and specific molecular pathways, showing it is well-tolerated as a potential nutritional supplement.
View Study (PubMed)BAICALEIN User Reviews & Experiences
*Based on large scale analysis of publicly available user experiences
User experiences are limited in the provided data, but scientific literature demonstrates consistent neuroprotective and anti-inflammatory effects in preclinical models. The compound shows promise for mood, anxiety, and cognitive support, though human clinical data remains limited.
BAICALEIN Benefits, Dosage & Side Effects
- Neuroprotection: Reduces neuroinflammation and oxidative stress in brain tissue through multiple molecular pathways
- Mood Enhancement: Demonstrates antidepressant-like effects in animal models by modulating neurotransmitter systems
- Anti-inflammatory Action: Suppresses microglial activation and inhibits pro-inflammatory cytokine production
- Cognitive Support: Protects against neurodegenerative processes and supports mitochondrial function in neurons
- Preclinical Evidence: Strong animal model data showing consistent benefits across depression, anxiety, and neuroprotection studies
- Mechanism Clarity: Well-documented molecular mechanisms including Nrf2/HO-1, NLRP3 inflammasome, and MAPK pathway modulation
- Bioavailability Considerations: Flavonoid compound with potential absorption limitations requiring appropriate formulation or delivery methods
- Clinical Translation: Promising preclinical results warrant human clinical trials to confirm therapeutic efficacy and optimal dosing
- Research Doses: Animal studies typically use doses ranging from 10-100 mg/kg body weight depending on condition
- Human Equivalence: Direct human equivalent doses need clinical validation but may range from moderate to higher supplemental doses
- Timing: Effects on neuroinflammation and neuroprotection suggest benefits from consistent daily administration
- Formulation: Bioavailability may be enhanced through specific delivery systems or combination with other compounds
- General Tolerability: Literature indicates baicalein is well-tolerated in preclinical studies with minimal adverse effects reported
- Interaction Potential: As a bioactive flavonoid, may interact with cytochrome P450 enzymes affecting drug metabolism
- Limited Human Data: Side effect profile in humans requires more clinical investigation
- Dosing Considerations: Higher doses may require monitoring though specific toxicity thresholds not well-established in humans
- Natural Source: Derived from Scutellaria baicalensis (Chinese skullcap), available as standardized extracts
- Supplement Market: Available through specialized supplement vendors focusing on nootropics and herbal compounds
- Research Status: Primarily studied in preclinical models with emerging interest for clinical application
Related Compounds
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