ANANDAMIDE

This systematic review identified clinical interventions that can enhance the endocannabinoid system by upregulating cannabinoid receptors, increasing ligand synthesis, or inhibiting ligand degradation, particularly relevant for conditions associated with endocannabinoid deficiency syndrome including migraine, fibromyalgia, and psychological disorders.

The endocannabinoid system regulates intestinal barrier integrity, and targeting it through microbial interventions may help address disorders like inflammatory bowel disease, obesity, and major depressive disorder by reducing inflammation and bacterial metabolite translocation.

The endocannabinoid system is a major brain modulatory network regulating homeostasis, development, learning, memory, mood, and energy metabolism, with loss of ECS control potentially affecting mood disorders, obesity, and overall quality of life.

Vaccenic acid supplementation increased anandamide levels and suppressed intestinal inflammation, demonstrating that dietary interventions can modulate the endocannabinoid system to reduce inflammation.

Exercise may serve as an effective adjunctive treatment for cannabis use disorder by modulating the endocannabinoid system, particularly through effects on anandamide and related endocannabinoids.

Anandamide demonstrated anti-proliferative and pro-apoptotic effects on colorectal cancer cells through CB1 receptor and lipid raft mechanisms, suggesting potential therapeutic applications in cancer treatment.

Omega-3 fatty acid consumption affects anandamide synthesis and stimulates formation of specific endocannabinoid-related conjugates with overlapping biological activities, providing promising leads for inflammatory and neurological disorder treatment.

Caloric restriction produced beneficial effects in depression and epilepsy models through modulation of the endocannabinoid system, including effects on anandamide levels.