AGARICUS BLAZEI
Tried AGARICUS BLAZEI? Be part of the collective knowledge. Share your experience - your insights help others on their journey.
What Is AGARICUS BLAZEI?
Agaricus blazei Murill (ABM), also known as the Brazilian mushroom or jisongrong, is a medicinal mushroom containing bioactive compounds including β-glucans, polysaccharides, polypeptides, and ergosterol. It works primarily through immunomodulation, antioxidant activity, and modulation of the Th1/Th2 immune balance, with demonstrated effects on inflammation, oxidative stress, and metabolic pathways including Keap1/Nrf2/ARE signaling.
AGARICUS BLAZEI Research & Studies
01 The mushroom Agaricus Blazei Murill in combination with metformin and gliclazide improves insulin resistance in type 2 diabetes: a randomized, double-blinded, and placebo-controlled clinical trial ▸
In a randomized controlled trial of 72 type 2 diabetes patients, ABM extract (1500 mg daily for 12 weeks) combined with standard diabetes medications significantly improved insulin resistance measured by HOMA-IR.
View Study (PubMed)02 Dietary supplementation with Agaricus blazei murill extract prevents diet-induced obesity and insulin resistance in rats ▸
ABM supplementation protected rats against high-fat diet-induced obesity, insulin resistance, glucose intolerance, and inflammation markers without reducing food intake, suggesting metabolic benefits independent of caloric restriction.
View Study (PubMed)03 Agaricus blazei polypeptide exerts a protective effect on D-galactose-induced aging mice via the Keap1/Nrf2/ARE and P53/Trim32 signaling pathways ▸
A novel 3 kD polypeptide from ABM significantly improved antioxidant markers (T-AOC, CAT) and reduced oxidative stress (MDA, ROS) in aging mice through activation of key longevity-related signaling pathways.
View Study (PubMed)04 Phase I Clinical Study of the Dietary Supplement, Agaricus blazei Murill, in Cancer Patients in Remission ▸
Safety study of 78 cancer survivors taking 1.8-5.4g ABM daily for 6 months found only 12% experienced adverse events (mostly mild digestive issues), with no dose-dependent toxicity, supporting safety at tested dosages.
View Study (PubMed)05 Hot water extract of Agaricus blazei Murrill specifically inhibits growth and induces apoptosis in human pancreatic cancer cells ▸
ABM hot water extract demonstrated specific anti-cancer activity against human pancreatic cancer cell lines through induction of apoptosis, suggesting potential therapeutic applications for pancreatic cancer.
View Study (PubMed)06 The beneficial effects of Agaricus blazei Murrill on hepatic antioxidant enzymes and the pancreatic tissue recovery in streptozotocin-induced diabetic rats ▸
ABM extracts, particularly ethyl acetate extract, improved hepatic antioxidant enzyme activity (SOD, CAT, glutathione) and promoted pancreatic tissue recovery in diabetic rats, suggesting hepatoprotective and pancreatic regenerative effects.
View Study (PubMed)07 Gastroprotective effect of hydroalcoholic extract from Agaricus blazei Murill against ethanol-induced gastric ulcer in mice ▸
ABM extract demonstrated protective effects against ethanol-induced gastric ulcers in mice, showing gastroprotective properties through anti-inflammatory and antioxidant mechanisms.
View Study (PubMed)08 Hypolipidemic effect of the edible mushroom Agaricus blazei in rats subjected to a hypercholesterolemic diet ▸
1% ABM supplementation for 6 weeks significantly reduced total cholesterol, non-HDL cholesterol, and atherogenic index while decreasing abdominal fat weight in rats fed a high cholesterol diet.
View Study (PubMed)09 Pro-inflammatory effects of the mushroom Agaricus blazei and its consequences on atherosclerosis development ▸
In ApoE-deficient mice, 6-12 weeks of ABM supplementation unexpectedly enhanced leukocyte activation and migration, potentially increasing atherosclerosis development, raising safety concerns for cardiovascular-compromised individuals.
View Study (PubMed)AGARICUS BLAZEI User Reviews & Experiences
*Based on large scale analysis of publicly available user experiences
User experiences show mixed results, with some incorporating ABM into comprehensive stacks for immune and metabolic support, while others question the value relative to cost and express concerns about over-supplementation. Limited standalone discussion suggests ABM is typically used as part of broader supplement regimens rather than as a primary intervention.
AGARICUS BLAZEI Benefits, Dosage & Side Effects
- Immune Support: Users incorporate ABM alongside other medicinal mushrooms for general immune function and wellness support
- Metabolic Benefits: Some users include ABM in stacks aimed at testosterone support and weight management, though often combined with many other compounds
- General Wellness: Mentioned in comprehensive anti-aging and longevity-focused supplement regimens
- Cost Concerns: Users frequently note that mushroom supplements including ABM can be expensive relative to perceived benefits
- Limited Standalone Data: Most Reddit users take ABM as part of complex multi-supplement stacks, making isolated effects difficult to assess
- Supporting Role: Typically used as a complementary ingredient rather than primary therapeutic agent in user protocols
- Research-Practice Gap: Strong research support for metabolic and immune benefits, but limited user discussion of specific effects
- Professional Guidance: Users seeking significant health improvements are frequently advised to consult healthcare providers rather than rely on supplement stacks alone
- Clinical Range: Research studies used 1,500-5,400 mg daily of ABM extract, typically divided into 2-3 doses
- Mushroom Blends: Users commonly take 143-1,000 mg of ABM mycelium as part of multi-mushroom formulations
- Duration: Clinical safety established for 6-12 weeks; some users report longer-term use as part of maintenance stacks
- Fermented Forms: Some brands offer fermented ABM claiming improved bioavailability, though user verification is limited
- Digestive Issues: Clinical trials reported mild nausea and diarrhea in about 12% of users, typically non-serious
- Allergic Reactions: One documented case of liver dysfunction related to food allergy/drug lymphocyte product in clinical study
- Cardiovascular Concerns: Research in ApoE-deficient mice showed pro-inflammatory effects and potential atherosclerosis promotion, suggesting caution for those with cardiovascular issues
- Generally Well-Tolerated: Most users and studies report good tolerability with minimal adverse effects at recommended doses
- Multiple Brands: Available from companies like quality brands, SoTru, and various medicinal mushroom specialists, with varying forms (powder, capsules, fermented)
- Quality Concerns: Users express difficulty verifying quality and active compound content, with brands often unable to provide comprehensive COAs or research backing fermentation claims
- Pricing: Considered expensive by users, particularly in proprietary blends, with bulk powder forms potentially more cost-effective
Related Compounds
Community Reviews
Share your experience with AGARICUS BLAZEI and help others make informed decisions.
Write a Review
Sign in to leave a review