ADIPONECTIN
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What Is ADIPONECTIN?
Adiponectin is a hormone secreted by adipose tissue that plays crucial roles in regulating glucose levels, fatty acid breakdown, and insulin sensitivity. It acts through activation of AMP-activated protein kinase (AMPK) pathways and has anti-inflammatory, anti-diabetic, and cardioprotective properties. Low adiponectin levels are associated with obesity, type 2 diabetes, and cardiovascular disease.
ADIPONECTIN Research & Studies
01 Adiponectin deficiency contributes to the development and progression of benign prostatic hyperplasia in obesity ▸
Study found that adiponectin deficiency in obesity causally links to BPH development, and adiponectin supplementation protected obese mice from microscopic BPH by inhibiting the MEK-ERK-p90RSK pathway and promoting apoptosis in prostatic cells.
View Study (PubMed)02 Fish oil supplementation increases concentration of adiponectin in healthy dogs ▸
Fish oil supplementation (220 mg/kg daily) significantly increased serum adiponectin concentrations by 3.4-5.3 µg/mL in healthy dogs without affecting body weight or fat percentage, suggesting omega-3s can boost adiponectin levels.
View Study (PubMed)03 The Effect of Omega-3 on Circulating Adiponectin in Adults With Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials ▸
Meta-analysis evaluating omega-3 fatty acid supplementation effects on adiponectin levels in type 2 diabetes patients, examining whether fish oil or EPA/DHA supplements can modulate this important metabolic hormone.
View Study (PubMed)04 Effects of green tea supplementation on serum concentrations of adiponectin in patients with type 2 diabetes mellitus: a systematic review and meta-analysis ▸
Systematic review examined green tea supplementation effects on adiponectin in type 2 diabetes patients, as decreased adiponectin is associated with obesity-related diseases including insulin resistance and cardiovascular disease.
View Study (PubMed)05 Adiponectin stimulates angiogenesis in response to tissue ischemia through stimulation of amp-activated protein kinase signaling ▸
Research demonstrated that adiponectin promotes angiogenesis and tissue repair through AMPK activation, with adiponectin-knockout mice showing impaired ischemic limb recovery that was reversed by adiponectin supplementation.
View Study (PubMed)06 Development of arterial calcification in adiponectin-deficient mice: adiponectin regulates arterial calcification ▸
Study found that adiponectin-deficient mice developed arterial calcification, which was attenuated by adiponectin supplementation through p38 MAPK pathway activation, suggesting adiponectin protects against vascular calcification.
View Study (PubMed)07 Adiponectin Attenuates Streptozotocin-Induced Tau Hyperphosphorylation and Cognitive Deficits by Rescuing PI3K/Akt/GSK-3β Pathway ▸
Adiponectin supplementation significantly restored cognitive function and attenuated tau hyperphosphorylation in diabetic rat models by activating the PI3K/Akt/GSK-3β pathway, suggesting neuroprotective effects against diabetes-related brain damage.
View Study (PubMed)08 Adiponectin alleviates contractile dysfunction of genioglossus in rats exposed to chronic intermittent hypoxia ▸
Adiponectin supplementation (10 µg twice weekly) significantly improved genioglossal muscle function in rats exposed to chronic intermittent hypoxia, suggesting potential benefits for sleep apnea-related muscle dysfunction.
View Study (PubMed)09 Effect of dietary lipids on circulating adiponectin: a systematic review with meta-analysis of randomised controlled trials ▸
Comprehensive meta-analysis of 53 RCTs examining how different dietary lipid interventions affect adiponectin concentrations, providing insights into nutritional strategies for modulating this important metabolic hormone.
View Study (PubMed)ADIPONECTIN User Reviews & Experiences
*Based on large scale analysis of publicly available user experiences
User discussions around adiponectin-boosting supplements are generally positive, with multiple users reporting significant weight loss benefits (513 calories/day in some studies) and metabolic improvements. Natural substances that increase adiponectin like omega-3s, green tea, and specific herbal formulations receive favorable feedback for their effectiveness and safety profile.
ADIPONECTIN Benefits, Dosage & Side Effects
- Metabolic Enhancement: Users report increased fat burning and energy expenditure, with studies showing up to 513 extra calories burned per day when adiponectin-boosting supplements are combined with calorie deficit and exercise
- Cardiovascular Protection: Research demonstrates adiponectin protects against arterial calcification, improves angiogenesis, and supports vascular health through anti-inflammatory mechanisms
- Cognitive Benefits: Adiponectin supplementation showed neuroprotective effects in studies, restoring cognitive function and reducing tau hyperphosphorylation in diabetic models
- Anti-Inflammatory Action: Multiple studies confirm adiponectin reduces systemic inflammation and oxidative stress, particularly beneficial for obesity-related metabolic conditions
- Weight Loss Enhancement: Most effective in overweight/obese individuals with adiponectin deficiency; normal-weight individuals have baseline adequate levels and see minimal benefit from supplementation attempts
- Synergistic Effects: Adiponectin-boosting compounds work best when combined with caloric restriction and regular exercise (20-30 minutes daily walking minimum), with minimal effects when used alone
- Natural Boosters: Omega-3 fish oil, green tea extract, curcumin, and specific herbal formulations (Meratrim) have proven effective at increasing adiponectin levels in clinical trials
- Context-Dependent: In chronic kidney disease and advanced metabolic conditions, high adiponectin may represent a compensatory response rather than causative benefit, making interpretation context-sensitive
- Fish Oil Protocol: 220 mg/kg daily or standard omega-3 supplementation shown to increase adiponectin by 3.4-5.3 µg/mL without side effects
- Meratrim Formulation: 400 mg twice daily of Sphaeranthus indicus and Garcinia mangostana extract shown effective in obesity studies with proper macronutrient ratios (60% carbs, 25% fat, 15% protein)
- Green Tea Extract: Various doses studied in type 2 diabetes populations for adiponectin modulation, with systematic reviews supporting efficacy
- Direct Supplementation: Animal studies used 10 µg adiponectin twice weekly intravenously; human direct supplementation protocols not well-established in available research
- Minimal Direct Toxicity: Natural adiponectin-boosting supplements like fish oil and green tea show excellent safety profiles with long histories of use
- Individual Response Variation: Some users report that adiponectin-boosting compounds only work under specific conditions (calorie deficit, exercise), with no effect when these conditions aren't met
- Kidney Considerations: In chronic kidney disease, elevated adiponectin may indicate disease severity rather than protection; supplementation strategies should be medically supervised in renal patients
- Interaction Concerns: Compounds affecting adiponectin also influence insulin sensitivity and glucose metabolism, requiring monitoring in diabetic patients on medication
- Indirect Boosting: Adiponectin itself is not commonly available as a direct supplement; users increase levels through proven natural compounds like omega-3s, curcumin, green tea extract, and specific herbal formulations
- Research Use: Direct adiponectin supplementation is primarily used in research settings via adenovirus-mediated delivery or intravenous administration in animal models, not commercially available for human use
Related Compounds
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