Adaptogens
22 compounds in this category
Adaptogens are a class of herbs and compounds that help the body resist physical, chemical, and biological stressors. The concept originates from Soviet research in the 1940s-60s. Modern research has validated several adaptogens with human clinical trials, particularly for cortisol modulation and fatigue reduction.
Caution
Effects are generally subtle and build over days to weeks. Adaptogens are not acute fixes for stress. Some adaptogens affect thyroid or hormone levels with sustained use.
Good to Know
Adaptogens work best for chronic stress, not acute crises. They tend to normalize rather than push in one direction, which is why side effects are generally mild. Cycling (8-12 weeks on, 2-4 weeks off) is a common community practice, though evidence for cycling necessity varies.