Expression of inflammation-related genes in mouse spleen under tuftsin analog Selank

Summary: This study investigated how the synthetic peptide Selank and its fragments affect genes involved in inflammation in mice. Results showed significant changes in the expression of 34 inflammation-related genes, confirming Selank’s role in regulating inflammation, particularly by influencing genes crucial for immune system development.

Link: ScienceDirect

The temporary dynamics of inflammation-related genes expression under tuftsin analog Selank action

Summary: The study investigated the effects of the synthetic peptide Selank and its fragment Gly-Pro on the expression of genes related to inflammation in the mouse spleen, finding significant changes in gene expression levels shortly after administration. Notably, both Selank and Gly-Pro similarly influenced multiple genes, suggesting Gly-Pro’s active role in the overall impact of Selank on the immune system.

Link: ScienceDirect

Selank Administration Affects the Expression of Some Genes Involved in GABAergic Neurotransmission

Summary: This study found that Selank, a peptide, induces significant changes in the expression of numerous genes involved in neurotransmission, similar to GABA. The results suggest that one of Selank’s possible mechanisms of action might be through modulating the GABAergic system, akin to how classical benzodiazepines work.

Link: The Department of Molecular Basis of Human Genetics, Institute of Molecular Genetics Russian Academy of Sciences

Peptide-based Anxiolytics: The Molecular Aspects of Heptapeptide Selank Biological Activity

Summary: This study investigated how the heptapeptide Selank works to reduce anxiety by examining its molecular interactions with GABA receptors. The results suggest that Selank acts as a positive allosteric modulator of GABA receptors, potentially offering anti-anxiety effects without the cumulative side effects found in traditional anxiolytics like benzodiazepines.

Link: Institute of Molecular Genetics, Russian Academy of Sciences

Physiological Effects of Selank and Its Fragments

Summary: Researchers developed Selank, a drug inspired by the natural peptide tuftsin, to combine natural biological activity with enhanced physiological functions. They analyzed experimental and clinical data, summarizing Selank’s benefits like reducing anxiety, improving cognition, and stimulating the immune system, suggesting it works through the enkephalin pathway.

Link: Institute of Molecular Genetics, Russian Academy of Sciences

Use of Selank to correct measures of integrative brain activity and biogenic amine levels in adult rats resulting from Antenatal Hypoxia

Summary: The study found that Selank, a peptide compound, significantly improved sensory attention, learning, and investigative behaviors in adult rats who experienced low oxygen conditions before birth. Additionally, Selank helped restore the balance of serotonin and noradrenaline in their brains, suggesting potential for treating long-term effects of such early-life hypoxia.

Link: Institute of Cell Biophysics, Russian Academy of Sciences

The effectiveness of selank in the treatment of adjustment disorder

Summary: This study found that nearly 50% of the Ukrainian population may develop non-psychotic mental health disorders, like Adjustment Disorder (AD), due to significant stressors. The research demonstrated that the treatment with selank, a synthetic peptide, significantly reduced symptoms associated with AD, such as somatic complaints, nutritional problems, and alcohol misuse compared to a control group.

Link: Ukrainian Scientific Research Institute of Neurology and Psychiatry

Peptide Selank Enhances the Effect of Diazepam in Reducing Anxiety in Unpredictable Chronic Mild Stress Conditions in Rats

Summary: This study found that Selank, a potential anti-anxiety drug, works similarly to traditional benzodiazepines like diazepam and can alter their effects. Specifically, Selank alone was effective in reducing anxiety levels, especially in non-stress conditions, while combining Selank with diazepam was most effective in reducing anxiety under chronic stress.

Link: Department of Molecular Basis of Human Genetics, Institute of Molecular Genetics

Selank and Short Peptides of the Tuftsin Family in the Regulation of Adaptive Behavior in Stress

Summary: Researchers studied different male rats and mice to evaluate how ten peptide compounds, including Selank, affect emotional stress in conflict situations. The peptides showed positive emotional and antistress effects, indicating potential for creating safe and effective stress-relief medications.

Link: V. V. Zakusov Research Institute of Pharmacology, Russian Academy of Medical Sciences