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Retatrutide

What is it?

Retatrutide is an experimental obesity drug by Eli Lilly that targets three hormone receptors and has achieved significant weight reduction in adults without diabetes in a phase 2 trial.

What does science research say?

Retatrutide, A Trigonal Glp-1, Gip And Glucagon Receptor Agonist, And Its Role In Weight Reduction

Summary: The study found that retatrutide significantly reduces weight, waist circumference, and BMI in overweight adults and also improves various cardiometabolic parameters such as blood pressure and cholesterol levels. It was well-tolerated with a good safety profile.

Link: ScienceDirect

Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomized, double-blind, placebo and active-controlled, parallel-group, phase 2 trial conducted in the USs

Summary: This study found that retatrutide, a new drug for managing type 2 diabetes, significantly improved blood sugar control and reduced body weight across various doses, with its effectiveness being higher than with placebo and dulaglutide for most doses. The safety profile was consistent with similar medications, and the findings will help determine appropriate dosages for future research phases.

Link: ScienceDirect

The Effect Of Triple-Hormone-Receptor Agonist Retatrutide, A Novel Medication For Weight Loss, On Blood Pressure – A Meta-Analysis Of Randomized Controlled Phase 2 Trials

Summary: Retatrutide, a new drug for weight loss, has shown potential to significantly lower both systolic and diastolic blood pressure based on results from two phase 2 trials. However, these findings need to be confirmed by larger phase 3 trials to better understand its cardiovascular benefits.

Link: ScienceDirect

Recent advances in peptide-based therapies for obesity and type 2 diabetes

Summary: Recent studies on incretin-based peptide therapies, including semaglutide and tirzepatide, have shown significant benefits in treating type 2 diabetes and obesity, such as lowering blood sugar levels and body weight. These therapies may also offer heart and kidney protection, though they can sometimes cause mild-to-moderate gastrointestinal side effects.

Link: ScienceDirect

Retatrutide showing promise in obesity (and type 2 diabetes)

Summary: The study evaluated the effectiveness of retatrutide in treating obesity and found that it led to significant weight loss over 24 weeks, though it frequently caused gastrointestinal side effects like nausea and diarrhea. The expert opinion suggests that, while the results are promising, retatrutide’s potential heart rate increase could undermine some benefits, and there is a need for comparison studies with existing treatments like semaglutide and tirzepatide.

Link: PubMed

A review of an investigational drug Retatrutide, a novel triple agonist agent for the treatment of obesity

Summary: Obesity is a significant public health issue, and there is a demand for new treatments that can manage body weight and associated health conditions. The study highlights retatrutide, a new drug in Phase III trials, which has shown promising weight loss results in earlier trials, pointing towards its potential in treating obesity and related diseases.

Link: PubMed

What do user think?
Overall sentiment*

*Based on large scale analysis of publicly available user experiences, the higher it is the better overall opinions of users on efficiency, safety, availability, etc.

Category: Effective

Retatrutide is effective; many users experience significant weight loss and health improvements, but there are reservations due to side effects like fatigue and nausea.

Main insights

Effects
  • Users commonly report significant weight loss with Retatrutide, including decreases in body fat percentage and reductions in specific areas like abdominal fat.
  • Many experience improvements in health markers, such as normalized blood pressure, improved cholesterol levels, and resolution of conditions like fatty liver disease and asthma symptoms.
  • Appetite suppression varies among users; some feel a strong decrease in hunger and “food noise,” while others notice minimal or delayed effects, often after several weeks.
  • Retatrutide may take 2–4 weeks to show noticeable effects, with some users reporting increased energy levels and metabolism over time.

Effectiveness
  • Retatrutide is generally considered highly effective for weight loss, with users losing substantial amounts over weeks to months, sometimes exceeding initial goals.
  • The supplement helps break through weight loss plateaus encountered with other medications, sustaining weight loss over time.
  • Users report improved health indicators, including better cholesterol levels and insulin resistance, contributing to overall health benefits.

Dosage & Administration
  • Starting doses commonly range from 1 mg to 4 mg per week, with gradual increases to higher doses like 8 mg or 12 mg based on effectiveness and tolerability.
  • Retatrutide is administered via subcutaneous injection, typically on a weekly basis; some users adjust the schedule or split doses to manage side effects.
  • Slow titration is emphasized to minimize side effects, and some users combine Retatrutide with other medications under medical supervision.

Side Effects
  • Gastrointestinal issues such as nausea, gas, bloating, and diarrhea are common initial side effects, often diminishing as the body adjusts.
  • Some users experience increased resting heart rate and fatigue, particularly during the initial weeks or at higher doses.
  • Skin sensitivity, described as a sunburn-like pain or allodynia, is reported by some users but may subside over time or with dose adjustments.
  • Overall, side effects are generally manageable and milder compared to those of similar medications.

Availability & Sourcing
  • Retatrutide is currently accessible primarily through clinical trials, with anticipated market approval around 2026, making it challenging to obtain outside these studies.
  • Some users obtain Retatrutide through peptide suppliers or research channels, but caution is advised regarding the legitimacy and safety of these sources.
  • Accessibility is limited, and costs may be high due to lack of insurance coverage; verifying the legitimacy of suppliers is important to ensure product authenticity.
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Disclaimer
The information on this website is provided for educational and informational purposes only. It is not intended as medical advice, diagnosis, or treatment. The products discussed are not approved for human use unless explicitly stated. Always consult a qualified healthcare professional before using any supplements, medications, or research compounds. We do not guarantee the accuracy, completeness, or reliability of the information presented. Use at your own risk.

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