Dopamine Club

Pramiracetam

What is it?
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Pramiracetam is a nootropic drug used primarily in some European countries to treat memory and attention deficits in elderly patients with dementia.

What does science research say?

Pramiracetam effects on scopolamine-induced amnesia in healthy volunteers

Summary: The study investigated pramiracetam’s ability to counteract memory loss induced by scopolamine in healthy male volunteers of varying ages. Results showed that while scopolamine impaired episodic memory and attention, pramiracetam partly reduced these amnesic effects compared to a placebo in both younger and older participants.

Link: PubMed

Pharmacokinetics of oral pramiracetam in normal volunteers

Summary: A study on pramiracetam, a potential cognition-enhancing drug, assessed its pharmacokinetics in healthy male volunteers who received varying doses in a controlled clinical trial. The drug showed predictable absorption and clearance rates without significant side effects, and the concentrations in the blood increased in proportion to the dose administered.

Link: PubMed

Placebo-controlled study of pramiracetam in young males with memory and cognitive problems resulting from head injury and anoxia

Summary: This study found that 400 mg of pramiracetam sulphate taken three times daily significantly improved memory, particularly delayed recall, in males with brain injuries compared to a placebo. These memory improvements persisted during an 18-month period on the medication and for one month after stopping the medication.

Link: PubMed

A new one-trial test for neurobiological studies of memory in rats. II: Effects of piracetam and pramiracetam

Summary: The study assessed the impact of nootropic drugs Piracetam and Pramiracetam on rats’ recognition memory using a new one-trial test based on spontaneous exploratory behavior. It found that specific doses of Pramiracetam (30 mg/kg) and Piracetam (400 mg/kg) significantly improved the rats’ ability to recognize a familiar object after 24 hours, without affecting their overall exploratory behavior, indicating the test’s utility for memory research in rats.

Link: ScienceDirect

Some neurochemical properties of pramiracetam (CI-879), a new cognition-enhancing agent

Summary: The study investigated the effects of pramiracetam sulfate, a new cognition-enhancing agent, and found it did not affect levels of various neurotransmitters or interact with several types of brain receptors. However, pramiracetam significantly increased choline uptake in the hippocampus, suggesting it may enhance cognitive functions by boosting hippocampal acetylcholine turnover.

Link: Warner-Lambert/Parke-Davis Pharmaceutical Research

Nootropic drugs in Alzheimer’s disease

Summary: The study tested pramiracetam on Alzheimer’s patients and found that while some showed initial improvement, it wasn’t consistent during follow-up phases, and brain scans showed no significant changes. Overall, pramiracetam at doses up to 4,000 mg does not appear effective in alleviating symptoms of Alzheimer’s disease.

Link: ScienceDirect

Using HPLC to analyze (S)-oxiracetam and four related substances in the bulk drug of (S)-oxiracetam

Summary: Scientists have developed and validated a precise analytical method using high-performance liquid chromatography (HPLC) to analyze (S)-oxiracetam and its impurities in bulk drug form. This method, which includes the use of specific columns and detection measures, has been proven to be highly reliable and can be used for quality control and monitoring the stability of (S)-oxiracetam in pharmaceutical practices.

Link: National Institutes of Neurological Disorders and Stroke

What do user think?
Overall sentiment*

*Based on large scale analysis of publicly available user experiences, the higher it is the better overall opinions of users on efficiency, safety, availability, etc.

Category: Mostly Effective

Pramiracetam is Mostly Effective because many users report enhanced focus and cognitive performance, though experiences vary and some users encounter side effects like headaches and emotional numbness.

Main insights

Effects
  • Users commonly report enhanced focus, productivity, and mental clarity when using Pramiracetam, enabling them to concentrate deeply on complex tasks.
  • Some experience improved memory and creativity, while a few note emotional blunting, describing a robotic or detached feeling that reduces emotional responsiveness.

    Effectiveness
    • Pramiracetam’s effectiveness varies among individuals; many find it highly effective, especially when the right dosage is found, while others notice subtle or no effects.
    • The benefits may be more pronounced when taken acutely or cycled, as frequent use can diminish its effectiveness for some users.

      Dosage & Administration
      • Typical dosages range from 100 mg to 600 mg per day, taken once or divided into two doses, with some users starting low to assess tolerance.
      • Pramiracetam is usually taken in capsule form to avoid its extremely unpleasant taste, and is often combined with a choline source like Alpha GPC or Citicoline to enhance benefits and reduce side effects such as headaches.

      Side Effects
      • Reported side effects include headaches, often attributed to inadequate or excessive choline intake, and emotional blunting, where users feel less empathy or emotional depth.
      • The supplement’s bitter and caustic taste is a common complaint, leading users to encapsulate it; serious side effects are rare and generally mild.

        Availability & Sourcing
        • Pramiracetam’s availability can be limited due to regulatory pressures, with some suppliers out of stock or having ceased operations.
        • Users emphasize purchasing from reputable vendors to ensure product quality and authenticity, though it may be expensive and sourcing can vary based on location.
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        Disclaimer
        The information on this website is provided for educational and informational purposes only. It is not intended as medical advice, diagnosis, or treatment. The products discussed are not approved for human use unless explicitly stated. Always consult a qualified healthcare professional before using any supplements, medications, or research compounds. We do not guarantee the accuracy, completeness, or reliability of the information presented. Use at your own risk.

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