Noopept in the treatment of mild cognitive impairment in patients with stroke

Summary: A study involving 60 stroke patients treated with noopept for 12 months showed significant cognitive improvements after 2 months, as measured by neuropsychological tests. Noopept, given at 20 mg daily, was found to enhance cognitive functions and is considered safe.

Link: PubMed

Clinical and electroencephalographic characteristic of noopept in patients with mild cognitive impairment of posttraumatic and vascular origin

Summary: The study examined the impact of a new nootropic drug, noopept, on brain activity in patients with cognitive and asthenic issues caused by trauma or vascular brain diseases, finding that it increased alpha- and beta-rhythm power while reducing delta-rhythm power in EEGs. These changes suggest that noopept has a nonspecific activating and anxiety-reducing effect, with more pronounced EEG improvements in patients with cerebral vascular diseases compared to those with posttraumatic brain lesions.

Link: PubMed

Effect of nootropic dipeptide noopept on CA1 pyramidal neurons involves α7AChRs on interneurons in hippocampal slices from rat

Summary: Noopept (NP) boosts activity in the brain’s hippocampal neurons by enhancing the firing of certain inhibitory interneurons, a process that is influenced by nicotinic acetylcholine receptors (nAChRs). Specifically, blocking α7 nAChRs stops NP’s effects, suggesting these receptors are crucial to how NP affects neuronal activity.

Link: PubMed

Effects of noopept on cognitive functions and pubertal process in rats with diabetes

Summary: This study explored the effects of noopept on pubertal diabetes using male rats and found that noopept helped to normalize delayed puberty and lowered blood glucose levels in diabetic rats. Additionally, noopept reduced insulin resistance in diabetic rats treated with insulin and improved certain markers in the hippocampus and testes, suggesting potential benefits in treating pubertal diabetes.

Link: PubMed

QbD-driven development of dissolving microneedle patch loaded with ultradeformable liposomes encapsulated Noopept: Exploring a patient friendly, once-daily option to manage dementia

Summary: This study aimed to improve the poor oral bioavailability of Noopept by developing ultradeformable liposomes (UDL) incorporated into a microneedle patch for transdermal delivery. The optimized formulation showed enhanced bioavailability, effective skin penetration, and safety, potentially allowing for reduced dosage and improved patient compliance.

Link: PubMed

Neuroprotective and Nootropic Drug Noopept Rescues α-Synuclein Amyloid Cytotoxicity

Summary: This study found that noopept, a drug with brain-boosting and protective properties, helps mitigate the harmful effects of α-synuclein, a protein linked to Parkinson’s disease, by promoting its aggregation into less toxic forms. This process, facilitated by hydrophobic interactions, improves cell survival and reduces oxidative stress in a cell model, suggesting potential additional benefits for Parkinson’s treatment.

Link: ScienceDirect

Novel nootropic dipeptide Noopept increases inhibitory synaptic transmission in CA1 pyramidal cells

Summary: Researchers studied the effects of the dipeptide Noopept on brain cells responsible for inhibitory signals in the hippocampus and found that Noopept increased the frequency of certain types of inhibitory signals without affecting others. This effect is likely due to the activation of specific inhibitory neurons, which the study confirmed through additional recordings.

Link: ScienceDirect

Noopept stimulates the expression of NGF and BDNF in rat hippocampus

Summary: This study found that the nootropic drug Noopept increases the expression of neurotrophic factors in the rat hippocampus, potentially enhancing cognitive functions like memory. The research suggests Noopept could be promising for preventing Alzheimer’s disease in patients with mild cognitive impairment and should be evaluated as a treatment in early stages of the disease.

Link: V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences

The Potential Influence of Noopept, a Nootropic Agent, on Depression and Mood: An Investigative Analysis

Summary: This study reviews the potential of noopept, a synthetic peptide, in treating depression and mood disorders, noting its effects on brain chemicals and protective properties. While noopept’s cognitive benefits are well-researched, its use for depression needs more investigation, which this paper emphasizes.

Link: Islamic Azad University