In vitro evaluation of Poly(d,l-lactide-co-glycolide) polymer-based implants containing the α-melanocyte stimulating hormone analog, Melanotan-I

Summary: The study investigated how a melanotropic peptide, Melanotan-I (MT-I), is released from biodegradable implants made of a PLGA copolymer, observing a three-phase release pattern. The researchers found that factors like polymer degradation, molecular weight, and viscosity influence release rates, and that gamma radiation up to a 2.5 Mrad dose did not significantly affect the overall release duration.

Link: ScienceDirect

An unhealthy glow? A review of melanotan use and associated clinical outcomes

Summary: This study reviewed existing literature on the effects of the synthetic-tanning products Melanotan I and II, finding both minor side effects and potential serious harms, including systemic toxidrome and melanoma, often linked to unregulated online sources. The review highlights the need for better clinical reporting and further research on long-term health outcomes and user demographics.

Link: ScienceDirect

Controlled-Release Delivery System for the α-MSH Analog Melanotan-I Using Poloxamer 407

Summary: The study aimed to create a controlled-release formulation of Melanotan-I (MT-I) using poloxamer 407 (P407) with various additives and found that formulations with methylcellulose (MC) or hydroxypropyl methylcellulose (HPMC) released MT-I the slowest, indicating their potential for prolonged delivery. In vivo testing in guinea pigs showed extended peptide release from these formulations compared to MT-I in solution.

Link: ScienceDirect

An in-depth case examination of an exotic dancer’s experience of melanotan

Summary: This study examines the experiences of an exotic dancer using the synthetic tanning agent melanotan, documenting her safe injecting practices, positive self-confidence outcomes, and awareness of the product’s risks and dependency potential. The findings highlight the need for policy recommendations regarding the regulation and safety of such synthetic tanning products.

Link: ScienceDirect

In vitro characterization and in vivo release profile of a poly (d,l-lactide-co-glycolide)-based implant delivery system for the α-MSH analog, Melanotan-I

Summary: Researchers developed a method to deliver Melanotan-I over a longer period by creating an implant using a biodegradable copolymer. This implant, tested on guinea pigs, showed a steady release of the drug over one month, as it slowly degraded in the body.

Link: ScienceDirect

Effect of MELANOTAN®, [Nle4, D-Phe7]-α-MSH, on melanin synthesis in humans with MC1R variant alleles

Summary: The study found that MELANOTAN® significantly increased melanin levels in the skin of 77 Caucasian participants, even more so in individuals with certain genetic variants of the MC1R gene, which typically reduce the drug’s binding efficacy. This indicates that MELANOTAN® could be particularly beneficial for those with these genetic variants, providing enhanced protection against UV radiation for those most in need.

Link: ScienceDirect