The structure of the antimicrobial human cathelicidin LL-37 shows oligomerization and channel formation in the presence of membrane mimics

Summary: The human cathelicidin LL-37 creates a narrow tetrameric channel in bacterial cell walls, leading to cell wall damage and cell death, offering potential for enhanced bactericidal activity.

Link: Springer Nature

Antimicrobial cathelicidin peptide LL-37 inhibits the pyroptosis of macrophages and improves the survival of polybacterial septic mice.

Summary: LL-37 improves survival in septic mice by suppressing macrophage pyroptosis, inflammatory cytokine production, and bacterial growth, making it a promising candidate for sepsis treatment.

Link: Oxford Academic

Ll-37, the Neutrophil Granule–And Epithelial Cell–Derived Cathelicidin, Utilizes Formyl Peptide Receptor–Like 1 (Fprl1) as a Receptor to Chemoattract Human Peripheral Blood Neutrophils, Monocytes, and T Cells

Summary: LL-37 contributes to innate and adaptive immunity by recruiting neutrophils, monocytes, and T cells to sites of microbial invasion by interacting with FPRL1.

Link: Journal of Experimental Medicine

Human cathelicidin LL-37 inhibits platelet aggregation and thrombosis via Src/PI3K/Akt signaling.

Summary: LL-37, a human cathelicidin, inhibits platelet aggregation and thrombosis by reducing Src/PI3K/Akt signaling, promoting antithrombotic effects.

Link: ScienceDirect

LL-37: Cathelicidin-related antimicrobial peptide with pleiotropic activity

Summary: LL-37 shows great potential as a broad-spectrum antibiotic with chemotactic and immunomodulatory properties, potentially benefiting various systems in the body.

Link: ScienceDirect

The Human Cathelicidin Antimicrobial Peptide LL-37 and Mimics are Potential Anticancer Drugs

Summary: The human cathelicidin LL-37 and its fragments show potential anticancer effects in various cancer cell lines, with potential therapeutic implications.

Link: Frontiers

Unique features of human cathelicidin LL‐37

Summary: Human cathelicidin LL-37 shows potential as a therapeutic agent against various bacterial and viral diseases, cancers, and hard-to-heal wounds, with potential applications in pharmacotherapy and pharmacotherapy.

Link: International Union of Biochemistry and Molecular Biology

A comprehensive summary of LL-37, the factotum human cathelicidin peptide.

Summary: LL-37, a human cathelicidin peptide, has pleiotropic effects, including antibacterial, antifungal, and antiviral properties, as well as a chemotactic and immunostimulatory effect, and potential roles in cancer.

Link: ScienceDirect

The human cathelicidin peptide LL-37 inhibits pancreatic cancer growth by suppressing autophagy and reprogramming of the tumor immune microenvironment

Summary: LL-37 inhibits pancreatic cancer growth by suppressing autophagy and reprogramming the tumor immune microenvironment, potentially offering a potential treatment for pancreatic cancer.

Link: Frontiers

New aspects of the structure and mode of action of the human cathelicidin LL-37 revealed by the intrinsic probe p-cyanophenylalanine.

Summary: Human cathelicidin LL-37 has unique structural characteristics and a different mode of action compared to rhesus monkey peptide RL-37, contributing to host defense and wound healing.

Link: Portland Press