Dopamine Club

Kisspeptin

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What is it?

Kisspeptin is a neuropeptide that plays a crucial role in regulating the reproductive axis in mammals. Initially identified for its role in suppressing metastasis in certain cancers, kisspeptin has since been recognized for its significant impact on the hypothalamic-pituitary-gonadal (HPG) axis, influencing puberty, fertility, and various reproductive processes.

What does science research say?

Kisspeptin and its Current Clinical Status- A Systematic Review.

Summary: Kisspeptin is a multipurpose drug with fewer side effects, promoting normal physiological processes in various conditions.

Link: Bentham Science

Kisspeptin and Polycystic Ovary Syndrome

Summary: Kisspeptin levels are higher in PCOS women, suggesting an over-active KISS1 system may contribute to irregular menstrual cycles and excessive androgen release in this population.

Link: Frontiers

Potential roles for the kisspeptin/kisspeptin receptor system in implantation and placentation

Summary: Kisspeptins and their receptor KISS1R play crucial roles in implantation and placentation, and their levels may serve as diagnostic markers for miscarriage and gestational trophoblastic neoplasia.

Link: Oxford Academic

The kisspeptin-GnRH pathway in human reproductive health and disease

Summary: Kisspeptin plays a key role in human reproduction, and manipulating its signaling may offer novel therapies for patients with low or high LH pulsatility.

Link: Oxford Academic

The role of kisspeptin in the control of gonadotrophin secretion.

Summary: Kisspeptins play a crucial role in regulating the hypothalamic-pituitary-gonadal axis and reproduction, integrating signals from internal and external sources.

Link: Oxford Academic

Kisspeptin signaling in the brain.

Summary: Kisspeptin signaling in the brain plays a key role in regulating reproduction, with potential applications in cancer regulation, vascular dynamics, placental physiology, and higher-order brain function.

Link: Oxford Academic

There is Kisspeptin – And Then There is Kisspeptin

Summary: Kisspeptin plays a significant role in regulating glucose homeostasis, insulin secretion, food intake, and body composition, with deficient signaling leading to reduced locomotor activity and increased adiposity.

Link: Cell Press Journal

Current Perspectives on Kisspeptins Role in Behaviour

Summary: Kisspeptin plays a wide-ranging role in behavior and mood, potentially benefiting therapies for common reproductive and related psychological and psychosexual disorders.

Link: Frontiers

The role of kisspeptin neurons in reproduction and metabolism.

Summary: Kisspeptin neurons play a crucial role in the hypothalamic-pituitary-gonadal axis, regulating energy balance and metabolism, potentially affecting sexual behavior.

Link: Journal of Endocrinology

Kisspeptin-54 stimulates the hypothalamic-pituitary gonadal axis in human males.

Summary: Elevating kisspeptin-54 levels significantly increases circulating LH, FSH, and testosterone levels in human males, providing a novel mechanism for hypothalamic-pituitary-gonadal axis manipulation in reproductive system disorders.

Link: LWW Journals

What do user think?
Overall sentiment*

*Based on large scale analysis of publicly available user experiences, the higher it is the better overall opinions of users on efficiency, safety, availability, etc.

Category: Mostly Effective
Generally helps libido and testosterone release, yet effects can be short-lived or highly variable person-to-person.

Main insights

Effects
  • Enhanced Libido and Sexual Function: The majority of users report significant improvements in libido, sexual desire, and erectile function after using kisspeptin.
  • Increased Hormone Production: Kisspeptin stimulates the release of luteinizing hormone (LH) and testosterone, supporting endogenous hormone production and hormonal balance.
  • Improved Mood and Energy Levels: Some users experience better mood, reduced anhedonia, increased energy, and enhanced cognitive function.
  • Variable Emotional Responses: A minority of users report emotional blunting, crying spells, or mood disturbances while using kisspeptin.
  • Genital Sensations: A few users experience genital numbness or changes in genital sensitivity, affecting overall sexual satisfaction.

Effectiveness
  • Effective for Sexual Health Enhancement: Most users find kisspeptin effective in boosting libido, sexual performance, and hormone regulation, viewing it as a promising advancement in hormone therapy.
  • Variable Results Among Users: While many experience positive outcomes, some users report minimal or no noticeable effects, indicating variability in individual responses and the potential need for dosage adjustments.
  • Comparisons to Other Treatments: Users often compare kisspeptin favorably to alternatives like hCG, noting similar benefits with fewer side effects, though some prefer hCG for its longer-lasting effects.
  • Recovery from Sexual Dysfunction: Some users have successfully recovered from symptoms like erectile dysfunction and reduced sperm count, suggesting effectiveness in addressing certain conditions.
  • Concerns About Temporary Benefits: A minority note that the benefits of kisspeptin are temporary and may cease if treatment is discontinued, highlighting the need for ongoing administration.

Dosage & Administration
  • Variable Dosing Regimens: Common dosages range from 100 mcg three times a week to 200 mcg per injection, with administration frequencies varying from twice weekly to multiple times daily due to kisspeptin’s short half-life.
  • Preferred Methods of Administration: Kisspeptin is typically administered via subcutaneous or intramuscular injections, with users emphasizing proper injection techniques to reduce discomfort.
  • Every Other Day Dosing Preference: Many users advocate for straightforward dosing schedules, such as dosing every 48 hours, to simplify administration and maintain consistent hormone levels.
  • Importance of Freshness and Storage: Users highlight that reconstituted kisspeptin peptides degrade rapidly, emphasizing the need for proper storage and timely use to maintain efficacy.
  • Lack of Standardized Guidelines: Due to limited research and individual variability, users often manage their own dosing schedules, indicating a need for professional guidance to determine optimal dosing.

Side Effects
  • Minimal Reported Side Effects: The majority of users report few or no significant side effects, suggesting that kisspeptin is generally well-tolerated when used appropriately.
  • Sexual Side Effects in Some Users: A minority experience sexual side effects such as genital numbness, decreased libido, reduced semen volume, or erectile dysfunction, particularly with higher dosages.
  • Potential Hormonal Fluctuations: Some users express concerns about hormonal instability, receptor desensitization, or downregulation of the hormonal axis with prolonged or frequent use.
  • Emotional and Physical Discomfort: A few users report mood changes, such as emotional blunting or crying spells, and physical symptoms like constipation or dull pain during erections.
  • Long-Term Safety Concerns: Users acknowledge limited research on kisspeptin’s long-term effects, expressing apprehension about potential risks associated with experimental or unregulated use.

Availability & Sourcing
  • Accessible Through Peptide Suppliers: Kisspeptin is available from various peptide suppliers, both domestically and internationally, often without the need for a prescription.
  • Trusted Suppliers Recommended: Users prefer reputable suppliers like Canlab, Peptide Sciences, and Limitless Life, emphasizing product quality and supplier transparency.
  • High Cost and Limited Availability: Kisspeptin can be more expensive than alternatives like hCG, with costs around $160 per vial, and may have limited availability due to production constraints and regulatory factors.
  • Authenticity Concerns: Some users express skepticism about the authenticity and quality of kisspeptin from certain suppliers, highlighting the importance of verifying product origins.
  • Regulatory and Regional Variations: Kisspeptin is not approved in some countries, leading users to obtain it from international sources or specialized clinics, and availability may be affected by regional regulations.
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Disclaimer
The information on this website is provided for educational and informational purposes only. It is not intended as medical advice, diagnosis, or treatment. The products discussed are not approved for human use unless explicitly stated. Always consult a qualified healthcare professional before using any supplements, medications, or research compounds. We do not guarantee the accuracy, completeness, or reliability of the information presented. Use at your own risk.

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