Epitalon

What is it?

Epitalon is a synthetic peptide believed to promote anti-aging by activating telomerase, thereby potentially extending the lifespan of human cells beyond their usual limits.

What does science research say?

AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism

Summary: The AEDG peptide (Epitalon) enhances the function of the pineal gland, retina, and brain, extending animal lifespan and reducing cancer risk, while also promoting neuronal cell differentiation. The study found that AEDG peptide increases the expression and synthesis of neurogenic differentiation markers in human gingival mesenchymal stem cells, possibly through binding with specific histones that interact with DNA.

Link: Saint Petersburg Institute of Bioregulation and Gerontology

Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice

Summary: In a study on female outbred Swiss-derived SHR mice, Epitalon treatment slowed down age-related estrous function decline, reduced chromosome aberrations in bone marrow cells, and extended the lifespan of the last 10% of survivors. Additionally, Epitalon significantly inhibited leukemia development but did not affect food consumption, body weight, mean lifespan, or total spontaneous tumor incidence, indicating its potential as a geroprotector and its safety for long-term use.

Link: Department of Carcinogenesis and Oncogerontology

Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice

Summary: The study examined the effects of the synthetic pineal peptide Epitalon on tumor development in mice and found that regular, small doses reduced the number of mice with malignant tumors and prevented cancer spread. Control mice developed metastases in reproductive organ tumors, whereas none of the Epitalon-treated mice did, suggesting the peptide has anti-metastatic properties.

Link: ResearchGate

Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/neu transgenic mice

Summary: The study found that treating HER-2/neu transgenic mice with the peptide Epitalon significantly reduced the number and size of mammary tumors, while also decreasing the size of lung metastases and downregulating HER-2/neu gene expression. In contrast, the peptide Vilon increased the incidence and number of mammary tumors, shortened the latency period, and resulted in higher HER-2/neu mRNA levels compared to saline-treated mice.

Link: Department of Carcinogenesis and Oncogerontology, N.N. Petrov Research Institute of Oncology

Effect of epitalon on the lifespan increase in Drosophila melanogaster

Summary: Researchers found that the synthetic peptide epitalon, when added to the developmental stage of fruit flies, extended their lifespan by 11-16% at extremely low concentrations. Interestingly, these effective concentrations were much lower than those required for melatonin, hinting at epitalon’s potent antioxidant and regulatory properties.

Link: St. Petersburg Institute of Bioregulation and Gerontology, North-West Branch of the Russian Academy of Medical Sciences

Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro

Summary: The study investigated the effects of Epitalon, a synthetic antioxidant peptide, on aging oocytes post-ovulation and found that it improved oocyte quality by reducing oxidative stress, spindle defects, and apoptosis while enhancing mitochondrial function. These results suggest that Epitalon can delay the aging process of oocytes in vitro by modulating mitochondrial activity and reactive oxygen species levels.

Link: Department of Biochemistry and Molecular Biology, Basic Medical College

Epitalon and colon carcinogenesis in rats: Proliferative activity and apoptosis in colon tumors and mucosa

Summary: This study investigated how the synthetic pineal peptide Epitalon affects cell growth in colon tumors and surrounding tissue in rats. They found that continuous treatment with Epitalon throughout the experiment significantly inhibited tumor cell division and increased cell death, showing the strongest overall protection against tumor development.

Link: Laboratory of Experimental Medicine

What do user think?

Overall sentiment*

*Based on large scale analysis of publicly available user experiences, the higher it is the better overall opinions of users on efficiency, safety, availability, etc.

Category: Mostly Effective

Based on the provided analyses, Epitalon is Mostly Effective, as the majority of users report improved sleep quality and other benefits like increased energy and potential anti-aging effects, though there are varying experiences with dosage effectiveness and some mild side effects noted.

Main insights

Effects

Improved Sleep Quality: Users commonly report significant enhancements in sleep, including faster onset of sleep, sleeping through the night without interruptions, experiencing vivid dreams, and better-regulated sleep patterns.

Increased Energy and Specific Health Benefits: Some individuals, particularly older users, experience increased energy levels and vitality, with specific improvements such as relief from restless leg syndrome, reduction in symptoms of retinitis pigmentosa (like eye flashing), and enhancements in eyesight.

Effectiveness

General Effectiveness in Sleep Improvement: Epitalon is generally considered effective for improving sleep quality and promoting daytime alertness, with benefits often building over time, especially when used in cycles.

Varied Responses Based on Dosage and Individual Factors: Effectiveness varies among individuals; older users and those using higher doses often report more pronounced benefits, though optimal dosing protocols and long-term effects remain uncertain among users.

Dosage & Administration

Common Dosage Ranges and Cycles: Users typically administer Epitalon via subcutaneous or intramuscular injections, with dosages ranging from 100 micrograms to 10 milligrams per day, usually over cycles of 10 to 20 days repeated several times a year.

Personalized Dosing Schedules: Due to variability in individual responses and protocols, users adjust dosages and timing, such as splitting doses or changing injection times (morning versus evening), to manage intensity and maximize benefits.

Side Effects

Mild and Manageable Side Effects: Some users experience mild side effects like sleep disturbances (e.g., insomnia or daytime tiredness), mood changes, or feeling slightly unwell, particularly when dosing is not properly adjusted.

Caution Against High Dosages: Serious adverse effects are not commonly reported, but users caution against high doses or improper cycling, noting that overdosage may lead to overstimulation or intensified side effects.

Availability & Sourcing

Challenges in Sourcing Quality Products: Availability of Epitalon varies, with users obtaining it from compounding pharmacies or various suppliers, but concerns about product quality and legitimacy make sourcing challenging.

Need for Careful Verification: Users emphasize the importance of verifying the purity and authenticity of Epitalon when purchasing, recommending reliance on reputable sources and cautious evaluation due to inconsistent dosage recommendations and limited definitive guidance.

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