Effect of the peptide bronchogen (Ala-Asp-Glu-Leu) on DNA thermostability

Summary: The study found that the peptide bronchogen increases the melting temperature of DNA, suggesting it acts as a stabilizing agent, although its effects do not change beyond a specific concentration range. Furthermore, bronchogen does not preferentially bind to specific DNA base pairs and binds strongly but occasionally to both strands of DNA, mainly interacting with nitrogen bases.

Link: PubMed

Short Exogenous Peptides Regulate Expression of CLE, KNOX1, and GRF Family Genes in Nicotiana tabacum

Summary: The study found that short peptides like epitalon, bronchogen, and vilon significantly influence the growth and development of tobacco plant cell cultures at very low concentrations, similar to how phytohormones work. These peptides modulate the expression of various genes involved in tissue formation and cell differentiation, suggesting potential applications in plant growth regulation and agricultural biotechnology.

Link: PubMed

Peptides tissue-specifically stimulate cell differentiation during their aging

Summary: The study found that certain short peptides can boost the expression of differentiation markers in human embryonic pancreatic, bronchial, and prostatic fibroblasts, even in aging cell cultures where these markers are typically reduced. This increased expression, particularly notable in older cells, suggests a potential anti-aging (geroprotective) effect of these peptides.

Link: PubMed

Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA

Summary: This study shows that short biologically active peptides can enter animal cells and their nuclei, potentially interacting with DNA and RNA. Different peptides uniquely affect fluorescence signals from labeled nucleic acids, indicating they can specifically bind to and recognize different DNA sequences, including those with specific epigenetic marks.

Link: PubMed

Modulating Effect of Peptide Therapy on the Morphofunctional State of Bronchial Epithelium in Rats with Obstructive Lung Pathology

Summary: The study found that therapy with the low-molecular-weight peptide Bronchogen for one month in rats effectively reversed structural damage and restored the immune and barrier functions of the bronchial epithelium caused by chronic obstructive pulmonary disease (COPD) induced by NO2 exposure. This treatment also improved local immunity and reduced inflammation, as indicated by the normalization of secretory IgA production and cytokine profiles.

Link: Research Institute of Pulmonology