What is it?
Bromantane is a drug known for its psychostimulant and immunostimulant properties, widely used in Russia for enhancing muscle performance and as a therapeutic agent. It has been the subject of various studies to understand its effects on physiology and behavior.
What does science research say?
Effects of bromantane on offspring maturation and development of reflexes
Summary: Bromantane has no adverse effects on reproduction and offspring development, with no significant differences in offspring weight gain or nervous system development compared to controls.
Link: ScienceDirect
Effect of bromantane, a new immunostimulating agent with psychostimulating activity, on the release and metabolism of dopamine in the striatum of freely moving rats. A microdialysis study
Summary: Bromantane increases dopamine release in the striatum of rats for 8 hours, with tetrodotoxin partially inhibiting this effect, and slightly decreasing dopamine metabolites.
Link: Springer Nature
Analysis of bromantane pharmacological spectrum
Summary: Bromantane has psychostimulatory and anxiolytic effects, with no effect on BALB/c mice and freezing prevention in C57B1/6 mice.
Link: Springer Nature
The effect of bromantane on the dopamin- and serotoninergic systems of the rat brain
Summary: Bromantan increases serotonin levels in the brain and affects dopamine levels, suggesting a role for dopaminergic system in its pharmacological effects.
Link: PubMed
The neuro- and psychophysiological effects of bromantane
Summary: Bromantan improves operators’ functional state, promoting moderate vigilance and productive action, and reducing tremors, potentially enhancing their working capacity in tired and extreme conditions.
Link: PubMed
A quantitative pharmaco-electroencephalographic analysis of the action of bromantane
Summary: Bromantane has more marked and prolonged stimulant properties than other adamantane psychostimulants, with a two-phase effect lasting up to 8 hours.
Link: PubMed
Kinetics of bromantane distribution in organs and tissues of rats for one-time administration of the drug
Summary: Bromantane distribution in organs and tissues of rats after one-time administration shows a rapid and steady increase in its concentration, suggesting its potential as an adaptogenic agent and detoxicant.
Link: Springer Nature
Effect of Carbon Dioxide on Bromantane Syntesis by Reductive Amination without an External Hydrogen Source
Summary: Carbon dioxide can both decrease and increase bromantane yield in reductive amination using carbon monoxide as a reducing agent, depending on the conditions.
Link: INEOS Open
Potential Synthetic Adaptogens. II. Synthesis and Pharmacological Activity of New Conformationally Labile Bromantane Analogs, N-[(Adamantan-1-YL)Methyl]-4-Bromoanilines
Summary: New conformationally labile bromantane analogs, N-[(Adamantan-1-YL)Methyl]-4-Bromoanilines, show potential as synthetic adaptogens with biological activity profiles influenced by adamantane substitution.
Link: Springer Nature
An acute toxicity study of bromantane
Summary: Bromantan’s therapeutic action is based on catecholaminergic effects, while cholinergic effects determine its toxic effects.
Link: PubMed
What do user think?
*Based on large scale analysis of publicly available user experiences, the higher it is the better overall opinions of users on efficiency, safety, availability, etc.
Category: Mostly Effective
Can elevate mood and motivation initially but may lose effectiveness over time or vary widely by individual.
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