What is it?
Armodafinil is a psychostimulant known for promoting wakefulness and improving cognitive functions such as attention and memory. It is the R-enantiomer of modafinil and has a longer half-life, making it effective for various conditions associated with excessive sleepiness and cognitive deficits.
What does science research say?
Armodafinil as a Potential Pharmacological Treatment for Attention Deficit Hyperactivity Disorder in Adults: A Review
Summary: Armodafinil shows potential as a useful treatment for ADHD in adults, improving wakefulness, memory, impulse control, and executive functions.
Link: Bentham Science
Adjunctive armodafinil for major depressive episodes associated with bipolar I disorder: a randomized, multicenter, double-blind, placebo-controlled, proof-of-concept study.
Summary: Adjunctive armodafinil 150 mg/d improved depressive symptoms in patients with bipolar depression, but not all measures, and was generally well-tolerated.
Adjunct armodafinil improves wakefulness and memory in obstructive sleep apnea/hypopnea syndrome.
Summary: Armodafinil improves wakefulness, memory, and reduces fatigue in patients with obstructive sleep apnea/hypopnea syndrome, while maintaining regular nCPAP use.
Armodafinil as adjunctive therapy in adults with cognitive deficits associated with schizophrenia: a 4-week, double-blind, placebo-controlled study.
Summary: Armodafinil 200 mg/d showed no improvement in cognitive measures but appeared to mitigate negative symptoms of schizophrenia, with treatment being generally well-tolerated.
Link: Psychiatrist.com
Armodafinil for treatment of excessive sleepiness associated with shift work disorder: a randomized controlled study.
Summary: Armodafinil significantly improves wakefulness during night shifts and overall clinical condition, while not affecting daytime sleep.
Link: Mayo Clinic Proceedings
Efficacy of Treatment With Armodafinil for Cancer-Related Fatigue in Patients With High-grade Glioma: A Phase 3 Randomized Clinical Trial.
Summary: Armodafinil treatment showed no significant reduction in cancer-related fatigue in patients with high-grade glioma, but may help corticosteroid users.
Link: JAMA Network
0672 The Effect Of Armodafinil On Sleep Spindles In Obstructive Sleep Apnea: Secondary Analysis Of A Randomized Placebo-controlled Trial
Summary: Armodafinil does not appear to enhance sleep spindle events during NREM sleep, which may enhance simulated driving performance in obstructive sleep apnea patients.
Link: Oxford Academic
Adjunctive armodafinil for major depressive episodes associated with bipolar I disorder.
Summary: Adjunctive armodafinil 150 mg/day reduced depressive symptoms in bipolar I disorder patients more effectively than placebo, but the difference was not statistically significant.
Link: ScienceDirect
A phase 3, double-blind, randomized, placebo-controlled study of armodafinil for excessive sleepiness associated with jet lag disorder.
Summary: Armodafinil at 150 mg/d significantly increased wakefulness and reduced sleep latency after eastward travel through 6 time zones.
Link: Mayo Clinic Proceedings
What do user think?
*Based on large scale analysis of publicly available user experiences, the higher it is the better overall opinions of users on efficiency, safety, availability, etc.
Category: Effective
Lauded for potent, long-lasting alertness and cognitive enhancement, although some experience side effects or tolerance.
Main insights
Effects |
|
Effectiveness |
|
Dosage & Administration |
|
Side Effects |
|
Availability & Sourcing |
|