What is it?
Adrafinil is a vigilance-enhancing pharmaceutical initially developed for the treatment of narcolepsy and to improve alertness, particularly in the elderly. It is metabolized into modafinil, which is the active form responsible for its effects.
What does science research say?
Behavioral Activating Effects of Adrafinil in Aged Canines
Summary: Adrafinil increases locomotor activity and directed sniffing in aged dogs, with some variability in individual responses.
Link: ScienceDirect
Identification of adrafinil and its main metabolite modafinil in human hair. Self-administration study and interpretation of an authentic case
Summary: Adrafinil and modafinil can be identified in human hair after a single consumption, suggesting that this was a trafficking case rather than self-consumption.
Link: Oxford Academic
Adrafinil disrupts performance on a delayed nonmatching-to-position task in aged beagle dogs
Summary: Adrafinil significantly impairs working memory in aged beagle dogs, potentially due to increased noradrenergic transmission in the prefrontal cortex.
Link: ScienceDirect
Adrafinil: Effects on behavior and cognition in aged canines
Summary: Adrafinil is a novel behavioral stimulant with cognitive enhancing potential in aged dogs, but its underlying mechanisms of action remain unknown.
Link: ScienceDirect
Oral Administration of Adrafinil Improves Discrimination Learning in Aged Beagle Dogs
Summary: Adrafinil significantly improves discrimination learning in aged beagle dogs, potentially due to enhanced vigilance and motivation.
Link: ScienceDirect
Fluorescent zinc and copper complexes for detection of adrafinil in paper-based microfluidic devices.
Summary: Fluorescent zinc and copper complexes provide an easy-to-detect fluorescence response for detecting adrafinil in paper-based microfluidic devices, making it a promising method for detecting banned performance-enhancing drugs.
Outsmarted by nootropics? An investigation into the thermal degradation of modafinil, modafinic acid, adrafinil, CRL-40,940 and CRL-40,941 in the GC injector: formation of 1,1,2,2-tetraphenylethane and its tetra fluoro analog.
Summary: Thermal degradation of modafinil, modafinic acid, adrafinil, CRL-40,940, and CRL-40,941 in a GC injector can produce 1,1,2,2-tetraphenylethane and its fluorinated analogue, potentially causing analysis.
Comparison of the effects of adrafinil, propentofylline, and nicergoline on behavior in aged dogs.
Summary: Adrafinil treatment may improve the quality of life for aged dogs by increasing exploratory behavior and alertness, while propentofylline and nicergoline show no significant effect.
Link: AVMA Publications
Development and Validation of an Analytical Method to Identify and Quantitate Novel Modafinil Analogs in Products Marketed as Dietary Supplements.
Summary: The developed LC-HRMS method effectively identifies and quantifies novel modafinil analogs in dietary supplements, preventing consumers from unknowingly consuming these active pharmaceutical ingredients.
What do user think?
*Based on large scale analysis of publicly available user experiences, the higher it is the better overall opinions of users on efficiency, safety, availability, etc.
Category: Mostly Effective
Users appreciate the wakefulness and focus boost but cite tolerance and liver concerns as limiting factors.
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