5-AMINO-1MQ

What is it?

5-amino-1MQ blocks the enzyme NNMT, which methylates compounds involved in detoxification and is active in various tissues, including the liver and brain. Increased NNMT activity is associated with diseases like cancer and Parkinson’s, making it a potential target for new therapies.

What does science research say?

Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high-fat diet-induced obesity in mice

Summary: NNMT inhibitors, including 5-amino-1MQ, reduced body weight, adipose tissue, and cholesterol levels in obese mice without impacting food intake. These inhibitors also increased NAD+ and SAM levels, highlighting NNMT as a promising target for obesity treatments.

Link: National Institutes of Health

Roles of Nicotinamide N-Methyltransferase in Obesity and Type 2 Diabetes

Summary: NNMT inhibition has shown potential in managing obesity and type 2 diabetes by enhancing energy expenditure, reducing fat mass, and improving insulin sensitivity. This study highlights NNMT as a therapeutic target, though more research is needed to clarify mechanisms and develop clinical applications.

Link: National Institutes of Health

Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice

Summary: 5-amino-1MQ combined with a low-fat diet in obese mice led to distinct gut microbiome changes, promoting weight loss and metabolic regulation. Microbial diversity patterns indicated unique profiles in treated mice, linking NNMT inhibition to microbiome-driven metabolic benefits.

Link: University of Texas Medical Branch

Preclinical testing of 5-amino-1-((1R,2S,3S,4R)-2,3-dihydroxy-4-methylcyclopentyl)-1H-imidazole-4-carboxamide: a potent protein kinase C-ι inhibitor as a potential prostate carcinoma therapeutic

Summary: This study tested a 5-amino-1MQ analog for prostate cancer treatment, showing reduced tumor growth and low toxicity in mice. Results support its potential as a safe cancer therapy, targeting protein kinase C-iota pathways to inhibit tumor progression.

Link: University of South Florida

Discovery of Novel N-Nicotinamide Methyltransferase Inhibitors to Combat Obesity-Linked Osteoarthritis and Metabolic Disease Among Veterans and Beneficiaries

Summary: This study developed new NNMT inhibitors aimed at reducing white adipose tissue and alleviating obesity-linked conditions. Early results in obese mouse models showed promising reductions in adiposity, indicating potential for NNMT inhibitors in treating metabolic diseases and osteoarthritis.

Link: University of Texas Medical Branch

What do user think?

Overall sentiment*

*Based on large scale analysis of publicly available user experiences, the higher it is the better overall opinions of users on efficiency, safety, availability, etc.

Category: Mixed

User feedback on 5-Amino-1MQ is mixed, with some individuals experiencing significant weight loss and increased energy, while others report minimal or no effects.

Main insights

Effects

Increased Energy and Stamina: Many users report heightened energy levels and improved stamina during workouts, feeling capable of longer or additional exercise sessions.

Fat Loss and Vascularity: Users, especially those with higher body fat percentages, notice significant fat loss and enhanced vascularity, particularly in the arms and legs.

Elevated Body Temperature: Some individuals experience an increase in body temperature and sweating more during physical activities.

Effectiveness

Variable Results: The effectiveness of 5-Amino-1MQ varies among users; some achieve notable weight loss and body fat reduction, while others observe minimal changes.

Significant Outcomes for Obese Individuals: Those with higher body fat percentages tend to see more pronounced fat loss compared to users who are already fit.

Comparisons with Other Supplements: Several users mention that alternatives like semaglutide may offer more significant results in weight loss and fat reduction.

Dosage & Administration

Typical Dosage Range: Common dosages range from 50mg to 150mg per day, with users often starting at a lower dose and gradually increasing to assess tolerance.

Oral Consumption: The supplement is primarily taken orally in capsule or liquid form, with some users creating their own capsules from powder.

Dosing Strategies: Some users divide their daily dose into multiple administrations to minimize potential side effects and may take a NAD+ booster before 5-Amino-1MQ.

Side Effects

Sleep Disturbances: Sleep disruptions, including difficulty falling asleep and altered sleep patterns, are reported by some users, particularly at higher dosages.

Initial Anxiety and Restlessness: A few individuals experience anxiety and restlessness when starting the supplement, which may diminish after a few weeks.

Injection Site Reactions: Users who administer the supplement via subcutaneous injections sometimes report painful lumps in fatty tissue.

Minimizing Adverse Effects: Starting with a low dose and gradually increasing may help reduce the frequency and severity of side effects.

Availability & Sourcing

Online Vendors: 5-Amino-1MQ is available from various online suppliers such as Peptide Sciences, Limitless Life Nootropics, Nootropic Source, and Swisschems.

Cost Considerations: The supplement is considered expensive, prompting some users to source internationally to reduce expenses.

Product Legitimacy: Users emphasize the importance of purchasing from reputable sources to ensure authenticity due to concerns about varying product quality.

Challenges in Sourcing: Finding trustworthy suppliers can be difficult, and users often seek recommendations to obtain a reliable product.

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